Cancer Studies

Ultrasonic synthesis of green lipid nanocarriers loaded with Scutellaria barbata extract: a sustainable approach for enhanced anticancer and antibacterial therapy.

Researchers developed lipid nanocarriers using ultrasonic waves to encapsulate Scutellaria barbata for anticancer and antibacterial benefits. Green technology synthesis enhances bioavailability, controlled release, and stability. Potential for eco-friendly drug delivery advancements.

Cancer Scutellaria barbata
Jetti R et al (2024).
Bioprocess Biosyst Eng.
DOI:
10.1007/s00449-024-03021-4
PubMed:
38647679

Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells.

Prohibitin (PHB) plays a role in breast cancer, with altered expression linked to reduced overall survival. Moringin (MG) interacts with PHB and other proteins, inducing apoptosis and inhibiting cell growth and migration. MG modulates multiple cancer-related targets in breast cancer cells.

Cancer Moringa oleifera
Srivastava A et al (2024).
Cell Signal.
DOI:
10.1016/j.cellsig.2024.111181
PubMed:
38643946

Marein, a novel natural product for restoring chemo-sensitivity to cancer cells through competitive inhibition of ABCG2 function.

Marein from Coreopsis tinctoria Nutt can sensitize drug resistant cancer cells by inhibiting ABCG2 transporter, increasing drug accumulation, and binding to critical site F439. Potential implications for treating ABCG2-expressing tumors with chemotherapeutic drugs.

Cancer Coreopsis tinctoria
Li Y et al (2024).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2024.116219
PubMed:
38643907

Revealing the mechanism of ethyl acetate extracts of Semen Impatientis against prostate cancer based on network pharmacology and transcriptomics.

They studied a Chinese medicine extract from Semen Impatientis against prostate cancer in vivo and found it to be effective. This research could potentially lead to new treatments for prostate cancer.

CancerGenetics Impatiens balsamina
Hu B et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118228
PubMed:
38643863

Targeting CD8(+) T cells with natural products for tumor therapy: Revealing insights into the mechanisms.

Scientists studied how natural compounds can enhance anti-tumor effects by boosting CD8 T cells' immune response. This research is important for improving cancer immunotherapy and overcoming therapeutic failure.

Cancer Ganoderma lucidum
Wang Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155608
PubMed:
38642413

Hedyotis diffusa Willd and Astragalus membranaceus May Exert Anti-colon Cancer Effects by Affecting AKTI Expression, as Determined by Network Pharmacology and Molecular Docking.

Using network pharmacology, researchers found that HDW and AM have potential anticancer properties against colon cancer. This information can guide treatment decisions for colon cancer patients.

CancerGastroenterology Hedyotis diffusa
Ren J et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099282388240405055003
PubMed:
38638040

Pistacia lentiscus L. revealed in vitro anti-proliferative activity on MCF-7 breast cancer cells and in vivo anti-mammary cancer effect on C57BL/6 mice through necrosis, anti-inflammatory and antioxidant enhancements.

Pistacia lentiscus essential oil inhibits breast cancer growth in vitro and in vivo by reducing inflammation and oxidative stress, suggesting potential as a preventive and therapeutic agent.

CancerImmunology Pistacia lentiscus
Abidi O et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0301524
PubMed:
38635559

Metabolome-microbiome insights into therapeutic impact of 8-O-acetylharpagide against breast cancer in a murine model.

8-O-acetylharpagide, a compound in Ajuga decumbens Thunb, reduces 4 T1 breast cancer growth in mice by regulating bile acid and arachidonic acid metabolism and altering gut microbiota. Promising for breast cancer treatment.

Cancer Ajuga decumbens
Qian J et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5880
PubMed:
38634147
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