Cancer Studies

Integrative Oncology Approaches to Supporting Immune Checkpoint Inhibitor Treatment of Solid Tumours.

This review explores how integrative oncology strategies can support immune checkpoint inhibitor treatment for adult solid tumors. It is important because it can inform decisions on integrating these strategies to enhance the effectiveness of ICI treatment.

Fuller-Shavel N and Krell J (2024).
Curr Oncol Rep.
PubMed:
38194216

Active components of Solanum nigrum and their antitumor effects: a literature review.

Researchers have found that plant-based herbal medicines, specifically [name], have strong anti-tumor properties. This review discusses the progress made in understanding the active constituents and their mechanisms, offering insights for the development of new clinical anticancer drugs.

Zhang H et al (2023).
Front Oncol.
PubMed:
38192621

Camptothecin bioprocessing from Aspergillus terreus, an endophyte of Catharanthus roseus: antiproliferative activity, topoisomerase inhibition and cell cycle analysis.

A strain of Aspergillus terreus in the medicinal plant Catharanthus roseus produces camptothecin (CPT), which exhibits anticancer and wound healing properties. Adding sterilized C. roseus leaves can restore CPT production, making A. terreus a potential source for industrial CPT production.

El-Sayed ASA et al (2024).
Microb Cell Fact.
PubMed:
38183118

Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis.

Coptisine, a compound from Chinese herb, has anti-tumor effect but its impact on rheumatoid arthritis (RA) is unclear. This study investigates coptisine's ability to control synovial proliferation in RA and its mechanism(s).

Xu F et al (2024).
Int Immunopharmacol.
PubMed:
38181676

Photoresponsive 'chemo-free' phytotherapy: formulation development for the treatment of triple-negative breast cancer.

Scientists developed a chemo-free treatment strategy for triple-negative breast cancer (TNBC) using a nanophytosomal system and phyto-photo dual treatment. Experiment showed promising anti-TNBC activity, suppression of mitochondrial potential, and induction of caspase-3 activity, indicating potential effectiveness and safety of this approach.

Maheshwari N and Sharma MC (2024).
Nanomedicine (Lond).
PubMed:
38179960

Anti-tumor effect of coix seed based on the theory of medicinal and food homology.

This article reviews the processing methods, anti-tumor activities, and clinical applications of Coix seed. It aims to provide information for further research and development of Coix seed as a medicine and food source.

Meng FD et al (2023).
World J Clin Oncol.
PubMed:
38179404

Preparation of polypeptide-metal complexes-coated Hosenkoside A and its inhibitory effect in cervical cancer.

Hosenkoside A from Impatiens balsamina seeds has anti-cervical cancer effects by inhibiting HDAC3, blocking STAT3 activation. Encapsulating it into PMC enhances targeted and sustained-release drug delivery, improving anti-tumor effects.

Wang Y et al (2024).
Int J Biol Macromol.
PubMed:
38176488

Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology.

Bitter melon inhibits breast cancer cell growth, but the exact process is unknown. Understanding the mechanism could lead to potential treatments for BRCA.

Panchal K et al (2023).
World J Exp Med.
PubMed:
38173546