Cancer Studies

Identification of Potential Phytochemical Inhibitors From Conium maculatum Targeting the Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer via Molecular Docking Analysis.

Scientists screened phytochemicals from a plant as potential inhibitors of EGFR in metastatic colorectal cancer (mCRC). 25 compounds had favorable drug-like properties, with 12 showing high affinity for EGFR. Seven compounds were predicted to be safe and effective, warranting further investigation and optimization.

CancerGastroenterologyPhytochemistry Conium maculatum
Venkateswaran S et al (2023).
Cureus.
DOI:
10.7759/cureus.48000
PubMed:
38034159

Assessment of antidiabetic, anti-inflammatory, antioxidant and anticancer activity competence of methonolic extracts of Trianthema ortulacastrum and Andrographis paniculata.

Methanol extracts from Andrographis paniculata have more beneficial compounds and higher antioxidant, antidiabetic, and anti-inflammatory activities compared to Trianthema portulacastrum. A. paniculata extract is worth exploring for potential biomedical applications.

CancerDiabetesImmunology Andrographis paniculata
Wadaan MA, Baabbad A and Farooq Khan M (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.117764
PubMed:
38029820

Exploring the anticancer potential of Actinidia chinensis Planch root extracts (acRoots) on hepatocellular carcinoma: A molecular mechanism study.

This study shows that has potential as a treatment for hepatocellular carcinoma (HCC), the seventh most prevalent cancer worldwide. It inhibits the growth and spread of HCC cells by blocking the AKT/mTOR signaling pathway, leading to cell death.

Cancer Actinidia chinensis
Qiu K et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21851
PubMed:
38027882

Green biosynthesis of silver and gold nanoparticles using Teak (Tectona grandis) leaf extract and its anticancer and antimicrobial activity.

The researchers used a green method to synthesize gold and silver nanoparticles using Teak extract. The silver nanoparticles showed significant anticancer activity, while the gold nanoparticles exhibited antibacterial and antifungal activity. These findings have potential medical applications.

AntimicrobialCancer Tectona grandis
Younis HM et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21698
PubMed:
38027825

Development of Statistically Optimized Piperine-Loaded Polymeric Nanoparticles for Breast Cancer: In Vitro Evaluation and Cell Culture Studies.

Piperine, derived from black pepper, has potential for breast cancer therapy. To improve its effectiveness, we created PPN-encapsulated nanoparticles. The optimized nanoparticles showed increased stability, sustained release, and exceptional cytotoxic effects on breast tumor cells. You should care because this formulation could enhance breast cancer treatment.

Cancer Piper nigrum
Gilani SJ, Bin-Jumah MN and Fatima F (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c06605
PubMed:
38027324

The efficacy of Allium ampeloprasum L. in reducing neutrophil recovery time in childhood cancer with febrile neutropenia: a randomized, double-blind, placebo-controlled trial.

Study evaluates effectiveness of L. in reducing neutrophil recovery time for children with chemotherapy-induced febrile neutropenia. Potentially important for managing treatment delays in patients.

Cancer Allium ampeloprasum
Bordbar M et al (2023).
Am J Blood Res.
PubMed:
38023416

Eco-friendly Cu/NiO nanoparticle synthesis: Catalytic potential in isatin-based chalcone synthesis for anticancer activity.

Isatin-based chalcones were synthesized using Cu/NiO nanoparticles as catalysts and showed potential as anticancer agents against MCF-7 cancer cells. Products 1 and 6 were particularly effective.

Cancer Annona muricata
Cahyana AH et al (2023).
MethodsX.
DOI:
10.1016/j.mex.2023.102471
PubMed:
38023319

Spatholobus suberectus inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway.

Scientists studied the effects of extract on lipogenesis and tumorigenesis in triple-negative breast cancer (TNBC) by activating specific signaling pathways. This research may provide insights into potential management strategies for TNBC.

Cancer Spatholobus suberectus
Zeng X et al (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.09.002
PubMed:
38020549
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