Cancer Studies

An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types.

This study investigates the chemical components of insect frass from Papilio machaon larvae fed on different plants and their biological activity. It also explores the expression of CYP genes in the larvae's midgut to understand their metabolic system. Care about this because it may reveal potential natural medicines and provide insights into insect metabolism.

CancerGastroenterology Foeniculum vulgareOenanthe javanica
Nakano M et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09841-0
PubMed:
38049715

Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review.

This study reviews the anti-cancer activity of triterpenoids from Chaga mushrooms. Promising results suggest triterpenoid supplementation could be a viable option in cancer treatment. Bioavailability challenges are also discussed.

Cancer Inonotus obliquus
Plehn S, Wagle S and Rupasinghe HPV (2023).
Curr Res Toxicol.
DOI:
10.1016/j.crtox.2023.100137
PubMed:
38046279

Anticancer, antioxidant, and antibacterial effects of nanoemulsion of Origanum majorana essential oil.

Researchers created a natural nanoemulsion with dual benefits: fighting bacteria and combating cancer. This has potential to lead to new treatments for both infectious diseases and cancer.

CancerImmunologyPhytochemistry Origanum majorana
Rasti F et al (2023).
Iran J Microbiol.
DOI:
10.18502/ijm.v15i4.13511
PubMed:
38045710

Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling.

TNBC has limited treatment options and poor prognosis. CAFs in the tumor microenvironment contribute to metastasis. Developing therapies targeting TNF-α and other key factors could improve outcomes for TNBC patients.

CancerImmunology Brucea javanica
Chen H et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154928
PubMed:
38043386

Molecular weight-dependent antitumor effects of prunes-derived type I arabinogalactan on human and murine triple wild-type melanomas.

Prune tea compounds (AGI-78KDa and AGI-12KDa) showed promise in reducing invasiveness and slowing proliferation in metastatic melanoma cells. In silico analysis indicated their potential therapeutic use and emphasized the significance of molecular weight for their antitumor effects.

Cancer Prunus domestica
Vaz da Luz KT et al (2023).
Carbohydr Res.
DOI:
10.1016/j.carres.2023.108986
PubMed:
38042036

Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca(2+) Signaling.

Researchers tested the extract of Artemisia vulgaris on breast cancer cells, leukemia cells, and fibroblasts. They analyzed its chemical composition and observed its effects. The findings may have implications for potential cancer treatments.

Cancer Artemisia vulgaris
Zamarioli LDS et al (2023).
Chin J Integr Med.
DOI:
10.1007/s11655-023-3712-2
PubMed:
38040876

Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464.

Bruceine D (BD) from Brucea javanica inhibits colorectal cancer (CRC) cell proliferation, invasion, and autophagy, while promoting apoptosis. This is mediated by BD's regulation of the circ_0068464/miR-520h/ATG5 axis, suggesting potential as a CRC treatment.

CancerGastroenterology Brucea javanica
Yang Y et al (2023).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14407
PubMed:
38040413

Antitumor Activity of a Lectin Purified from Punica Granatum Pulps against Ehrlich Ascites Carcinoma (EAC) Cells.

Scientists isolated a lectin from P. granatum fruit and discovered its potential anti-cancer properties. This could lead to new treatments or therapies for cancer.

Cancer Punica granatum
Nurujjaman et al (2023).
Anticancer Agents Med Chem.
DOI:
10.2174/0118715206269394231124093423
PubMed:
38037833
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