Cancer Studies

Aqueous Extracts of Ocimum gratissimum Mitigate Colitis and Protect Against AOM/DSS-Induced Colorectal Cancer in Mice.

Ocimum gratissimum extract reduced colorectal cancer (CRC) tumor load. Continuous administration was more effective than separated administration. OGE also reduced severe colitis, suggesting potential for preventing CRC by inhibiting inflammation.

Liu JY et al (2023).
Carcinogenesis.
PubMed:
37864831

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives.

Opuntia spp. has potential as an anticancer agent with effects on colorectal, melanoma, and breast cancer through apoptosis, cell cycle arrest, and oxidative stress. More studies, including animal experiments and clinical trials, are needed.

Wang J et al (2023).
Front Plant Sci.
PubMed:
37860248

YIV-818-A: a novel therapeutic agent in prostate cancer management through androgen receptor downregulation, glucocorticoid receptor inhibition, epigenetic regulation, and enhancement of apalutamide, darolutamide, and enzalutamide efficacy.

YIV-818-A, a botanical drug derived from Rubia cordifolia extracts, effectively inhibits castration-resistant prostate cancer (CRPC) and shows synergy with existing drugs. It has potential as an anti-prostate cancer drug with chemopreventive properties.

Lam W et al (2023).
Front Pharmacol.
PubMed:
37860121

In Vitro Assessment of The Bioactive Compounds and Anticancer Potential of Citrus medica Leaf Extract.

This study analyzed the biochemical constituents of plant leaves using FTIR and GC-MS. They found compounds with health benefits, such as omega-3 fatty acids. The leaves also exhibited antimicrobial and antioxidant activity, as well as anticancer activity. These findings suggest their potential use in nutraceuticals and functional foods.

Indira M et al (2023).
Trop Life Sci Res.
PubMed:
37860090

Explore intersection genes of oxymatrine and COVID-19 with lung cancer as potential therapeutic targets based on network pharmacology.

Oxymatrine, a natural alkaloid, has antiviral, anti-inflammatory, and immune regulatory effects. Research suggests it may be beneficial for lung cancer patients with COVID-19. Targets include immune regulation, cytoprotection, and control of signaling pathways. Oxymatrine may enhance current treatments for COVID-19 and lung cancer.

Wu W et al (2023).
J Med Microbiol.
PubMed:
37855710

Human schistosomiasis in Nigeria: present status, diagnosis, chemotherapy, and herbal medicines.

Nigeria has the highest burden of schistosomiasis in the world. This review summarizes the distribution, prevalence, diagnosis, treatment, and preventive measures. Limited use of diagnostic tools and preventive chemotherapy contribute to the high endemicity in Nigeria. The country has potential for discovering biomarkers and novel plant-derived treatments.

Saidu U et al (2023).
Parasitol Res.
PubMed:
37851179

Optimizing the extraction of polyphenols from the bark of Terminalia arjuna and an in-silico investigation on its activity in colorectal cancer.

Scientists studied the plant Terminalia arjuna, which is traditionally used in India for treating diseases. Its potential pharmacological activities are being investigated for potential use in repurposing drugs. Relevant for drug development.

Adhikary T and Basak P (2023).
Curr Comput Aided Drug Des.
PubMed:
37850546