Exosomal microRNA profiling revealed enhanced autophagy suppression and anti-tumor effects of a combination of compound Phyllanthus urinaria and lenvatinib in hepatocellular carcinoma.

Researchers investigated the combination of a Chinese herb called Phyllanthus urinaria (CP) with the drug lenvatinib for treating liver cancer. CP has strong anti-cancer effects and, when combined with lenvatinib, could potentially overcome drug resistance in patients with advanced liver cancer.

Liao M et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155091

PubMed:

37844378

New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer.

Ginkgo biloba leaves have been used for centuries as a traditional medicine. They have shown potential in preventing cancer, but the exact mechanism is not well understood.

Yu J et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155088

PubMed:

37844377

Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis.

Solasonine, a compound found in L., has shown anticancer effects on various cancers, including non-small cell lung cancer (NSCLC). This study aims to uncover its biological target and mechanism in NSCLC.

Liu T et al (2023).

PeerJ.

DOI:

10.7717/peerj.16195

PubMed:

37842037

Cell death induction and intracellular vesicle formation in human colorectal cancer cells treated with Δ(9)-Tetrahydrocannabinol.

Hwang YN et al (2023).

Genes Genomics.

DOI:

10.1007/s13258-023-01466-7

PubMed:

37837516

Exploring bixin from Bixa orellana L. seeds: quantification and in silico insights into its anti-cancer potential.

Bixin, a pigment found in seed arils, has potential anti-cancer activity. It may inhibit BRAF, MMP9, TNF expression, enhance TP53 expression, and interact with skin cancer targets with low binding energy. Bixin is stable and shows promise for skin cancer treatment.

Muthusamy K et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2268202

PubMed:

37837422

Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro.

Red kale extract reduces cancer cell viability and proliferation, induces cell apoptosis, and may cause cell cycle arrest. Bioactive compounds in red kale contribute to its anti-cancer effect, but more research is needed to understand their specific role.

Rachwał K et al (2023).

Molecules.

DOI:

10.3390/molecules28196938

PubMed:

37836781

Diversity, Antimicrobial, Antioxidant, and Anticancer Activity of Culturable Fungal Endophyte Communities in Cordia dichotoma.

Indian medicinal plant yields bioactive endophytic fungus, OP870014, with potent antimicrobial, antioxidant, and anticancer properties, introducing the possibility of using these fungi as a natural source of therapeutic compounds.

Sharma M et al (2023).

Molecules.

DOI:

10.3390/molecules28196926

PubMed:

37836769

Coumarins from Jinhua Finger Citron: Separation by Liquid-Liquid Chromatography and Potential Antitumor Activity.

Liquid-liquid chromatography was used to separate compounds from fingered citron extract. Five coumarin derivatives were isolated and evaluated for anti-tumor activity, with 5,7-dimethoxycoumarin showing the most potential for inhibiting cancer cell growth. This study informs future research on natural-product-based antitumor agents.

Wang C et al (2023).

Molecules.

DOI:

10.3390/molecules28196917

PubMed:

37836760