Cancer Studies

Cytotoxicity screening of Thymus vulgaris L. in breast cancer: in vitro study.

The study investigated the effects of the herbal medication L. on breast cancer cells. Results showed that L. significantly reduced cell proliferation, induced cell death, and suppressed migration and colony formation. The findings suggest that L. may be a potential treatment for breast cancer, but further research is needed.

Bıtgen N et al (2023).
Toxicol Res (Camb).
PubMed:
37663807

Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS.

The study found that a herbal melanin derived from Nigella sativa upregulated the TLR4 receptor, increased COX-2 expression, and promoted the secretion of PGE2 and IL-6 in AGS cells. This suggests that the melanin may have gastroprotective effects and potential benefits for gastric prevention and treatment.

El-Obeid A et al (2023).
BMC Complement Med Ther.
PubMed:
37658354

The apoptotic effect of the Lycopodium clavatum extracts on MCF-7 human breast cancer cells.

Lycopodium Clavatum (LC), an herb, was found to have cytotoxic and apoptotic effects on MCF-7 human breast cancer cells, indicating its potential as an anticancer agent. LC activates apoptosis-related proteins and shows promise as a natural compound for breast cancer treatment.

Kucukbagriacik Y et al (2023).
Med Oncol.
PubMed:
37658180

Euchronin A-F isolated from the Arnebia euchroma (Royle) Johnst. and their anti-proliferative activities in vitro.

Six new compounds called euchronin A-F and nine known compounds were discovered in Arnebia euchroma. Compounds 2 and 4 showed strong anti-proliferative activity against HaCaT cells, reducing cell viability to 38.83% and 68.44% at 25 μM concentration.

Zhang ZP et al (2023).
J Nat Med.
PubMed:
37658159

Correction: Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.

Correction: Leaf polysaccharides reverse tumor-associated macrophage phenotype targeting TLR4, promote T-cell infiltration, and exhibit anti-lung cancer effects. Important for understanding potential treatments and immunotherapies for lung cancer.

Wang S et al (2023).
Food Funct.
PubMed:
37655684

Comparison of Phytochemical Composition and Untargeted Metabolomic Analysis of an Extract from Cnidoscolus aconitifolius (Mill.) I. I. Johnst and Porophyllum ruderale (Jacq.) Cass. and Biological Cytotoxic and Antiproliferative Activity In Vitro.

Mexican plants CA and PR show promise in fighting colon cancer cells, with CA being particularly effective in reducing metabolic activity and inducing apoptosis. Further research is required, but these plants hold potential as sources of polyphenols for anticancer treatments.

Vargas-Madriz ÁF et al (2023).
Plants (Basel).
PubMed:
37653904