Ficus carica Latex Modulates Immunity-Linked Gene Expression in Human Papillomavirus Positive Cervical Cancer Cell Lines: Evidence from RNA Seq Transcriptome Analysis.

Fig latex has potential therapeutic properties against HPV-positive cervical cancer, enhancing the expression of genes involved in immune surveillance and antigen presentation. This could aid in the clearance of early-stage cancer and contribute to the development of safer treatment modalities.

Cakir MO et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms241713646

PubMed:

37686451

Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma.

Picrasidine J, a compound isolated from a plant, inhibits cell motility, migration, and invasion in head and neck squamous cell carcinoma (HNSCC). It also inhibits the expression of serine protease KLK-10 and phosphorylation of ERK. This suggests that picrasidine J could be a promising anticancer compound for preventing HNSCC metastasis and progression.

Ho HY et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms241713230

PubMed:

37686036

Low-Temperature Vacuum Drying on Broccoli: Enhanced Anti-Inflammatory and Anti-Proliferative Properties Regarding Other Drying Methods.

Scientists studied the effects of different drying methods on broccoli. Low-temperature vacuum drying (LTVD) preserved the most bioactive compounds and had high anti-inflammatory and anti-proliferative activities. Dried broccoli from LTVD can be used to develop natural products with these effects.

Vega-Galvez A et al (2023).

Foods.

DOI:

10.3390/foods12173311

PubMed:

37685242

Computational biology and in vitro studies for anticipating cancer-related molecular targets of sweet wormwood (Artemisia annua).

A. annua, a Chinese medicinal herb, has shown promise in inhibiting the growth of cancer cells. This may lead to the development of alternative and perhaps more effective treatments for cancer.

Dawood H, Celik I and Ibrahim RS (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04135-0

PubMed:

37684586

Novel biosynthesis of gold nanoparticles for multifunctional applications: Electrochemical detection of hydrazine and treatment of gastric cancer.

Researchers synthesized gold nanoparticles using olive fruit extract. They characterized the nanoparticles and found that they can be used to create a hydrazine sensor with good performance and exhibit cytotoxic properties against gastric cancer cells.

Yan K et al (2023).

Environ Res.

DOI:

10.1016/j.envres.2023.117081

PubMed:

37683794

Mollugin suppresses proliferation and drives ferroptosis of colorectal cancer cells through inhibition of insulin-like growth factor 2 mRNA binding protein 3/glutathione peroxidase 4 axis.

Mollugin, a compound from Rubia cordifolia, induces ferroptosis in colorectal cancer (CRC) cells by reducing GSH and increasing ROS, Fe, and MDA levels. Inhibition of ferroptosis reverses the antitumor effects of mollugin. High expression of IGF2BP3 in CRC suggests poor prognosis. Mollugin may be a promising CRC therapy by targeting the IGF2BP3/GPX4 axis.

Wang W et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115427

PubMed:

37677963

Author Correction: Potential anti-proliferative activity of Salix mucronata and Triticum spelta plant extracts on liver and colorectal cancer cell lines.

Ahmad GM et al (2023).

Sci Rep.

DOI:

10.1038/s41598-023-41534-2

PubMed:

37666911

The Role of Mitochondrial Dysfunction in Cytotoxic Effects of Solanum nigrum Water Extract on MCF-7 and MDA-MB-231 Breast Cancer Cells.

Study found that water extract (SNWE) can potentially kill MCF-7 and MDA-MB-231 cancer cells by causing mitochondrial dysfunction. Promising natural agent for cancer treatment.

Khan HA et al (2023).

Front Biosci (Landmark Ed).

DOI:

10.31083/j.fbl2808180

PubMed:

37664945