Deciphering the Anticancer Arsenal of Piper longum: Network Pharmacology and Molecular Docking Unveil Phytochemical Targets Against Lung Cancer.

Study used network pharmacology and omics to identify bioactive compounds in for potential lung cancer therapy. Key targets include CTNNB1, STAT3, HIF1A, HSP90AA1, and ERBB2. Compounds like 6-alpha-diol show promise for treatment.

Varadharajan V et al (2024).

Int J Med Sci.

DOI:

10.7150/ijms.98393

PubMed:

39113883

Evaluation of oral silymarin formulation efficacy in prevention of doxorubicin induced hepatotoxicity in patients with non-metastatic breast cancer.

Silymarin can help prevent chemotherapy-induced liver damage in breast cancer patients on doxorubicin-containing regimens. Consider adding silymarin to treatment plans to protect liver function.

Fatemi Shandiz A et al (2024).

J Oncol Pharm Pract.

DOI:

10.1177/10781552241268778

PubMed:

39110237

Studies on In Vitro Antimicrobial, Anticancer, and Anti-oxidative Inflammatory Response of Methanolic Tuber Extracts Derived From Terminalia chebula.

Study investigated antibacterial, antifungal, & anticancer effects of methanolic tuber extracts. Extracts showed cytotoxic effects on oral cancer cells, antioxidant & anti-inflammatory activities, and significant antibacterial effects. Potential therapeutic & commercial value, more research needed on active components and mechanisms.

Suresh Kumar D et al (2024).

Cureus.

DOI:

10.7759/cureus.63930

PubMed:

39109124

Untargeted LC/HRMS Metabolomics Analysis and Anticancer Activity Assay on MCF-7 and A549 Cells from Coleus amboinicus Lour Leaf Extract.

Study analyzed global cancer statistics, identifying breast cancer as top cause of death in women and lung cancer as second leading cause overall. Important for prioritizing research and resources in cancer prevention and treatment.

Gurning K et al (2024).

Iran J Pharm Res.

DOI:

10.5812/ijpr-143494

PubMed:

39108647

Determination of Antioxidant, Cytotoxicity, and Anti-human Lung Cancer Properties of Silver Nanoparticles Green-Formulated by Foeniculum vulgare Extract Combined with Radiotherapy.

Researchers synthesized silver nanoparticles using fennel leaf extract and tested them with radiotherapy on lung cancer cells. The nanoparticles showed potential for fighting cancer. This study may lead to new treatments for lung cancer.

Wu Q et al (2024).

Biol Trace Elem Res.

DOI:

10.1007/s12011-024-04332-z

PubMed:

39107456

Investigation of the phytochemical profiling and antioxidant, anti-diabetic, anti-inflammatory, and MDA-MB-231 cell line antiproliferative potentials of extracts from Ephedra alata Decne.

Study on Ephedra alata Decne extracts found high antioxidant properties, phenolic and flavonoid compounds. Acetone extract showed strongest antioxidant activity, possible anti-inflammatory, anti-diabetic, and anticancer effects. Important for potential medicinal uses.

Al Jaafreh AM et al (2024).

Sci Rep.

DOI:

10.1038/s41598-024-65561-9

PubMed:

39107351

Piperine enhances doxorubicin sensitivity in triple-negative breast cancer by targeting the PI3K/Akt/mTOR pathway and cancer stem cells.

PIP, a compound from black pepper, enhances DOX sensitivity in TNBC cells by suppressing PI3K/Akt/mTOR signaling and CSCs. Potential for decreasing chemoresistance. Important for developing new treatment strategies.

Hakeem AN et al (2024).

Sci Rep.

DOI:

10.1038/s41598-024-65508-0

PubMed:

39107323

Corrigendum to "Dissecting the antitumor effects of Scutellaria barbata: Initial insights into the metabolism of scutellarin and luteolin by gut microbiota" [J. Pharm. Biomed. Anal. 248 (2024) 116325].

Zhang X et al (2024).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2024.116393

PubMed:

39106746