Cardiology Studies

Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice.

Artesunate, extracted from Artemisia annua, reduces intestinal ischemia/reperfusion (II/R) induced lung injury in mice by targeting oxidative stress, inflammation, and apoptosis via AKT and HO-1 activation. Potential therapeutic candidate for II/R induced acute lung injury.

CardiologyGastroenterology Artemisia annua
Ji T et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.110571
PubMed:
37441813

Symptom-oriented network pharmacology revealed the mechanism of HuangQi-DanShen herb pair against cerebral ischemia coupled with comprehensive chemical characterization.

HuangQi-DanShen (HD) is a significant drug duo in traditional Chinese medicine used for treating cerebral ischemia.

Cardiology Salvia
Liu Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116845
PubMed:
37437791

Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Wogonoside in acute myocardial ischemia rats.

Scientists investigated the protective effects of Wogonoside (Wog) from Scutellaria baicalensis Georgi (SBG) on acute myocardial ischemia (AMI). Understanding these mechanisms could lead to potential treatments for cardiovascular diseases.

Cardiology Scutellaria baicalensis
Feng W et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116871
PubMed:
37393028

Protective effectiveness of anise against testicular ischemia and reperfusion injury: An experimental study in rats.

This study investigated the effects of Anise in treating testicular torsion. Anise was found to have protective effects against ischemia and reperfusion injury in rat testicles.

Cardiology Pimpinella anisum
Yildizhan E et al (2023).
Pol J Vet Sci.
DOI:
10.24425/pjvs.2023.145029
PubMed:
37389431

A new mechanism of therapeutic effect of stachydrine on heart failure by inhibiting myocardial ferroptosis.

Researchers investigated the effects of stachydrine, a compound from Leonurus japonicus Houtt. (Yimucao), on ferroptosis-induced heart failure. Stachydrine improved cardiac function and mitochondrial morphology, suggesting a potential treatment for cardiac ferroptosis and chronic heart failure.

Cardiology Leonurus japonicus
Liang Y et al (2023).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2023.175881
PubMed:
37385579

Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-β1 /Smads signaling pathway.

The researchers studied the LGQH decoction, a traditional Chinese medicine formula, and found it has cardioprotective effects on heart failure. The active ingredients and anti-fibrotic mechanism are still unknown.

Cardiology Atractylodes macrocephalaCinnamomum cassia
Shi Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116849
PubMed:
37385575

Discovery of Potent Angiotensin-Converting Enzyme Inhibitors in Pomegranate as a Treatment for Hypertension.

Pomegranate contains compounds that can inhibit ACE, a enzyme involved in blood pressure regulation. These compounds also stimulate nitric oxide production, improve glucose uptake, and reduce oxidative stress.

Cardiology Punica granatum
Ali MY, Jannat S and Chang MS (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c02115
PubMed:
37384918

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors.

Roselle, a medicinal plant, has bioactive compounds with anti-hyperlipidemia, anti-hyperglycemia, and anti-hypertension effects. It may be a potential therapy for cardiovascular diseases.

Cardiology Hibiscus sabdariffa
Sapian S et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16060807
PubMed:
37375755
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