GeoBotanical: Cardiology Studies

57.

Elucidating the mechanism of action of Radix Angelica sinensis (Oliv.) Diels and Radix Astragalus mongholicus Bunge ultrafiltration extract on radiation-induced myocardial fibrosis based on network pharmacology and experimental research.

RAS-RA, a key compound in traditional Chinese medicine, showed promise in treating radiation-induced myocardial fibrosis by targeting inflammation and the PI3K/AKT/mTOR pathway. It improved cardiac function, reduced collagen deposition, and protected liver and kidney functions. This study highlights RAS-RA's potential as a therapeutic agent for RIMF.

Cardiology Angelica sinensis

Ren C et al (2024).; Eur J Pharm Sci.
DOI:: 10.1016/j.ejps.2024.106794
PubMed:: 38788908

58.

Investigation of the molecular mechanism of Smilax glabra Roxb. in treating hypertension based on proteomics and bioinformatics.

Study explored protein expression in hypertension treated with Roxb. (SGR), showing potential for anti-inflammatory and immune system disease treatment. Important for developing SGR-based therapies.

Cardiology Smilax glabra

Yang X et al (2024).; Front Pharmacol.
DOI:: 10.3389/fphar.2024.1360829
PubMed:: 38783958

59.

Protective effects of Passiflora Incarnata on ischemia-reperfusion injury in testicular torsion: an experimental study in a rat model.

Study found PI may protect against injury after testicular torsion in rats. Could lead to new treatments for testicular injuries in humans.

Cardiology Passiflora incarnata

Azizoğlu M et al (2024).; Cir Cir.
DOI:: 10.24875/CIRU.23000416
PubMed:: 38782389

60.

Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling.

Puerarin (Pue) from Pueraria lobata protects against vascular damage induced by diabetes by reducing inflammation and oxidative stress through inactivating the ROS-NLRP3 signaling pathway. This could potentially lead to new treatments for diabetic vascular diseases.

Cardiology Diabetes Pueraria lobata

Wei H et al (2024).; J Cell Mol Med.
DOI:: 10.1111/jcmm.18239
PubMed:: 38774996

61.

Astrocyte modulation in cerebral ischemia-reperfusion injury: A promising therapeutic strategy.

82 drugs targeting astrocytes show promise for treating cerebral ischemia-reperfusion injury, with potential to reduce inflammation, oxidative stress, edema, and more. Traditional Chinese medicines like Salvia miltiorrhiza, Ginkgo, and Ginseng are particularly promising.

Cardiology Neuroscience Salvia Salvia miltiorrhiza

Wang Z et al (2024).; Exp Neurol.
DOI:: 10.1016/j.expneurol.2024.114814
PubMed:: 38762094

62.

Evaluation of Sechium edule fruit attenuation impact on the cardiomyopathy of the STZ-induced diabetic rats.

Chayote extract has high phenolic and flavonoid contents, reducing blood sugar and improving lipid profile in diabetic rats. It also lowers urea, creatinine, and liver enzyme levels, and improves ECG parameters. Promising for diabetes treatment, but more research needed on molecular mechanisms.

Cardiology Diabetes Sechium edule

Mohammad FS et al (2024).; Heliyon.
DOI:: 10.1016/j.heliyon.2024.e30440
PubMed:: 38742087

63.

The synchronized feature of Saururus chinensis and gut microbiota against T2DM, NAFLD, obesity and hypertension via integrated pharmacology.

Study uncovers therapeutic potential of gut microbiota and plant compounds for metabolic disorders. Key genes and bioactive compounds identified could lead to novel treatments for type 2 diabetes, NAFLD, obesity, and hypertension.

Cardiology Gastroenterology Obesity Saururus chinensis

Oh KK et al (2024).; Artif Cells Nanomed Biotechnol.
DOI:: 10.1080/21691401.2024.2350475
PubMed:: 38733373

64.

Benefits of Puerarin on Metabolic Syndrome and Its Associated Cardiovascular Diseases in Rats Fed a High-Fat/High-Sucrose Diet.

Puerarin from Pueraria lobata improved metabolic syndrome in rats, reducing cardiovascular damage, inflammation, and improving glucose and lipid metabolism. Dietary supplementation with PUE could be beneficial in managing and preventing MetS and CVDs.

Cardiology Pueraria lobata

Mu Y et al (2024).; Nutrients.
DOI:: 10.3390/nu16091273
PubMed:: 38732519