Diabetes Studies

Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction.

Cinnamaldehyde (CMD) improves bone strength and structure in diabetic osteoporosis (DOP) rats by inhibiting osteoclast activity through netrin-1/DCC/UNC5B signaling pathway. Relevant for treating bone diseases in diabetic patients.

Ji S et al (2024).
Front Pharmacol.
PubMed:
38628640

Drosophila melanogaster as a model organism for diabetes II treatment by the ethyl acetate fraction of Atriplex halimus L.

They studied Atriplex halimus fractions on Drosophila larvae to treat Type 2 diabetes. Results showed decreased glucose and increased weight. Eryodictyol-7-O-neohesperidoside may be a potential antidiabetic compound.

Montaser O et al (2024).
J Exp Zool A Ecol Integr Physiol.
PubMed:
38623920

Study on the potential hypoglycemic flavonoids in Abrus precatorius leaves: purification process, quality profile and activity mechanisms by transcriptomics and network pharmacology.

Study investigated flavonoids in leaves for hypoglycaemic effects. Found D resin best for purification, increasing purity to 85.2%. Transcriptomics and network pharmacology show potential hypoglycaemic role, providing basis for product development.

Yuan X et al (2024).
Nat Prod Res.
PubMed:
38623836

Analysis of Primary and Secondary Metabolites, Physical Properties, Antioxidant and Antidiabetic Activities, and Chemical Composition of Rosmarinus officinalis Essential Oils under Differential Water Stress Conditions.

Researchers found that increased water stress affects essential oil quality and bioactivity. Optimal water management can improve antioxidant and antidiabetic properties of essential oils, with implications for healthcare and agriculture.

Laftouhi A et al (2024).
ACS Omega.
PubMed:
38617605

Antidiabetic Properties of the Root Extracts of Dandelion (Taraxacum officinale) and Burdock (Arctium lappa).

Preclinical study on dandelion and burdock roots suggest potential antidiabetic properties. Burdock had higher antioxidant and hypoglycemic activity, dandelion had higher total polysaccharide. Further research needed for in vivo validation.

Zolotova D et al (2024).
Plants (Basel).
PubMed:
38611548

Edible wild plants, chicory and purslane, alleviated diabetic testicular dysfunction, and insulin resistance via suppression 8OHdg and oxidative stress in rats.

Chicory and purslane herbal extracts improve testicular function in diabetic rats by reducing blood sugar, lipid levels, inflammation, and oxidative stress while enhancing sperm, hormone levels, and testicular health. Promising for potential human applications.

Saad EA et al (2024).
PLoS One.
PubMed:
38603728

Antidiabetic effectiveness of Phyllanthus niruri bioactive compounds via targeting DPP-IV.

PNE from Linn. plant showed strong antioxidant and antidiabetic properties in mice. Phytochemicals in PNE may inhibit DPP-IV, making it a potential antidiabetic agent.

Bhushan V et al (2024).
Nat Prod Res.
PubMed:
38590294