Diabetes Studies

Polygonatum sibiricum (Huang Jing) polysaccharide reduces diabetic cardiomyopathy through increasing cyclic guanosine monophosphate-protein kinase G signaling in diabetic mice.

Researchers studied the potential benefits of Polygonatum sibiricum polysaccharide (PSP) in treating diabetic cardiomyopathy (DCM) in mice. Results may lead to new treatments for this common condition in diabetic individuals.

CardiologyDiabetes Polygonatum sibiricum
Lei S et al (2024).
J Diabetes Investig.
DOI:
10.1111/jdi.14192
PubMed:
38553792

From Flora to Pharmaceuticals: 100 new additions to angiosperms of Gafargaon subdistrict in Bangladesh and unraveling antidiabetic drug candidates targeting DPP4 through in silico approach.

Researchers identified 100 new angiosperm species in Gafargaon, Bangladesh, including Chamaecostus cuspidatus with potential for antidiabetic drug development. Virtual screening revealed two lead compounds with promising properties. Study enriches biodiversity knowledge and may lead to new diabetes treatments.

Diabetes Chamaecostus cuspidatus
Ahmed SS and Rahman MO (2024).
PLoS One.
DOI:
10.1371/journal.pone.0301348
PubMed:
38551991

Hypoglycemic activity in vivo and in vitro of the Lotus (Nelumbo nucifera Gaertn.) seed skin (testa) phenolic-rich extracts.

Study showed lotus seed skin phenolic-rich extract (LSSE) decreased blood glucose levels and α-glucosidase activity in mice. LSSE has potential as a natural hypoglycemic functional food.

DiabetesPhytochemistry Nelumbo nucifera
Xu H, Wang C and Gong L (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101282
PubMed:
38550890

Exploring the therapeutic mechanism of potential phytocompounds from Kalanchoe pinnata in the treatment of diabetes mellitus by integrating network pharmacology, molecular docking and simulation approach.

Researchers studied the bioactive compounds in a medicinal plant for potential anti-type-2 diabetes effects. Identified key targets and pathways through various analyses, showing promise for novel anti-diabetic treatments.

Diabetes Kalanchoe pinnata
Halayal RY et al (2024).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2024.102026
PubMed:
38550331

The Effects of Cranberry Consumption on Glycemic and Lipid Profiles in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Study found cranberry consumption decreased TC/HDL-C ratio and HOMA-IR in humans, suggesting potential lipid-lowering and hypoglycemic properties. Subgroup analysis showed dried forms may decrease fasting insulin. Consider incorporating cranberry for metabolic health.

Diabetes Vaccinium macrocarpon
Li X et al (2024).
Nutrients.
DOI:
10.3390/nu16060782
PubMed:
38542695

Efficacy of Pistacia lentiscus Plant (Rumi Mastagi) in Comparison to Levosulpiride in Patients with Diabetic Gastroparesis: A Double-Blind Non-Inferior Randomised Control Trial Study.

Study compared mastic gum and levosulpiride for treating diabetic gastroparesis. Mastic gum showed similar efficacy to levosulpiride in improving symptoms and gastric emptying. Potential new treatment option for DG.

Diabetes Pistacia lentiscus
Singh A et al (2024).
Indian J Endocrinol Metab.
DOI:
10.4103/ijem.ijem_84_23
PubMed:
38533281

Novel design and development of Centella Asiatica extract - loaded poloxamer/ZnO nanocomposite wound closure material to improve anti-bacterial action and enhanced wound healing efficacy in diabetic foot ulcer.

Researchers developed a nanocomposite of PLX/ZnO and CAE for diabetic wound healing. It promotes rapid healing, antimicrobial action, and cell proliferation, offering a promising treatment option for diabetic foot ulcers.

Diabetes Centella asiatica
Wang L et al (2024).
Regen Ther.
DOI:
10.1016/j.reth.2024.03.006
PubMed:
38532843

Enhanced hypoglycemic effects of konjac glucomannan combined with Polygonatum cyrtonema Hua polysaccharide in complete nutritional liquid diet fed type 2 diabetes mice.

Study: KGM and PCP supplement combo in T2DM mice on liquid diet improves postprandial glucose, long-term glucose metabolism. Benefits include gut health, weight, and liver function.

Diabetes Polygonatum cyrtonema
Chang L et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131121
PubMed:
38522692
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