Diabetes Studies

Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose-Streptozotocin-Induced Diabetic Rats.

A study found that the "leaves" plant extract's ethyl acetate fraction has strong potential for treating type 2 diabetes, as it inhibited α-glucosidase, increased glucose uptake in muscles, and improved pancreatic β-cell function, insulin sensitivity, and liver glucose metabolism.

Diabetes Tectona grandis
Sanni O, Nkomozepi P and Islam MS (2023).
Int J Mol Sci.
DOI:
10.3390/ijms25010028
PubMed:
38203195

Effects of swimming training in hot and cold temperatures combined with cinnamon supplementation on HbA1C levels, TBC1D1, and TBC1D4 in diabetic rats.

Researchers studied the impact of cold water swimming exercise and cinnamon supplements on HbA1C levels and two genes in diabetic rats. This non-drug approach could help prevent and improve diabetes in developing countries.

Diabetes Cinnamomum zeylanicum
Tayebi SM et al (2024).
Nutr Diabetes.
DOI:
10.1038/s41387-023-00256-0
PubMed:
38195613

An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia.

Scientists found that the calyxes of Hs contain anthocyanins that can regulate blood glucose levels in diabetic patients. Additionally, consuming Hs may potentially improve memory alterations caused by diabetes.

Diabetes Hibiscus sabdariffa
López-Pérez SJ, Ureña-Guerrero ME and Bañuelos-Pineda J (2024).
Nutr Neurosci.
DOI:
10.1080/1028415X.2023.2301166
PubMed:
38193451

Assessment of Phenolic Composition, Antioxidant Potential, Antimicrobial Properties, and Antidiabetic Activity in Extracts Obtained from Schinus molle L. Leaves and Fruits.

This study investigates the health benefits (antioxidant, antimicrobial, antidiabetic) of a specific plant grown in Turkey. Important for finding new natural remedies or improving existing treatments in various fields.

AntimicrobialDiabetesImmunologyPhytochemistry Schinus molle
İlgün S et al (2023).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2812353
PubMed:
38179764

The effects of Tripterygium wilfordii Hook F on renal outcomes in type 2 diabetic kidney disease patients with severe proteinuria: a single-center cohort study.

TwHF reduces proteinuria in patients with diabetic kidney disease (DKD), but its impact on renal outcomes remains unknown. This study examines the effects of TwHF on renal outcomes in DKD patients.

Diabetes Tripterygium wilfordii
Cheng Y et al (2024).
Ren Fail.
DOI:
10.1080/0886022X.2023.2295425
PubMed:
38178377

A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway.

Researchers created a dihydromyricetin-loaded hydrogel called PCD, which has antioxidant and anti-inflammatory properties. PCD promotes wound healing, showing potential to treat diabetic wounds.

Diabetes Phellinus igniarius
Yang J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.129124
PubMed:
38176509

Free radical scavenging polyphenols isolated from Phyllanthus niruri L. ameliorates hyperglycemia via SIRT1 induction and GLUT4 translocation in in vitro and in vivo models.

Phyllanthus niruri L., a medicinal plant, and its compounds were found to enhance glucose uptake, reduce ROS levels, and have potential for treating type 2 diabetes.

Diabetes Phyllanthus niruri
Swargiary D et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105803
PubMed:
38171388

Mulberry (Morus alba L.) leaf water extract attenuates type 2 diabetes mellitus by regulating gut microbiota dysbiosis, lipopolysaccharide elevation and endocannabinoid system disorder.

Researchers found that mulberry leaf water extract (MLWE) can improve type 2 diabetes by regulating gut microbiota and reducing intestinal permeability. This is important for understanding the potential benefits of MLWE in treating metabolic dysfunction.

DiabetesGastroenterology Morus alba
Du Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117681
PubMed:
38163557
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