Diabetes Studies

Research Progress on Application of Inonotus obliquus in Diabetic Kidney Disease.

Inonotus obliquus, a rare medicinal fungi, shows potential in treating diabetic kidney disease (DKD). This paper summarizes its biological activities, pharmacological effects, and latest progress in isolating metabolites for DKD treatment, providing valuable insights for potential application in DKD therapy.

Diabetes Inonotus obliquus
Wang S et al (2023).
J Inflamm Res.
DOI:
10.2147/JIR.S431913
PubMed:
38161352

Development of Oral Formulation of Lepidium Seeds Significantly Decreases the High Blood Glucose Levels in Diabetic Rats; In Vitro Formulation and In Vivo Antidiabetic Performance.

Researchers investigated the natural molecules in Garden Cress seeds that can reduce blood glucose levels. This could be significant in finding potential treatments for disorders related to high blood glucose.

Diabetes Lepidium sativum
Aldosari BN et al (2023).
Drug Dev Ind Pharm.
DOI:
10.1080/03639045.2023.2300649
PubMed:
38156891

Evaluation of the impact of polypeptide-p on diabetic rats upon its cloning, expression, and secretion in Saccharomyces boulardii.

Researchers evaluated the effectiveness of a recombinant protein from Momordica charantia on diabetic rats. They cloned the optimized gene sequence into a probiotic yeast and fed it to diabetic rats, resulting in a significant reduction in blood glucose levels. This study suggests a potential safe plant-based supplement for diabetes.

Diabetes Momordica charantia
Yamchi A et al (2023).
Arch Microbiol.
DOI:
10.1007/s00203-023-03773-9
PubMed:
38142245

Assessment of Chemical Composition and In Vitro Antioxidant, Antidiabetic, Anticholinesterase and Microbial Virulence-Quenching Effects of Salad Burnet (Sanguisorba minor L.) Harvested from Algeria.

This study evaluated the phytochemical content and antioxidant properties of extracts. The extracts exhibited high antioxidant and enzyme inhibition activities, as well as biofilm inhibition against certain pathogens. These findings suggest potential use as a food preservative.

DiabetesImmunology Sanguisorba minor
Haouam C et al (2023).
Plants (Basel).
DOI:
10.3390/plants12244134
PubMed:
38140461

Green Synthesis and Characterization of Silver Nanoparticles Using Azadirachta indica Seeds Extract: In Vitro and In Vivo Evaluation of Anti-Diabetic Activity.

Scientists studied the use of environmentally-friendly nanoparticles as a potential therapy for diabetes. This could provide a cost-effective and sustainable treatment option for a global, life-threatening syndrome.

Diabetes Azadirachta indica
Rehman G et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16121677
PubMed:
38139804

The Potential Role of Gossypetin in the Treatment of Diabetes Mellitus and Its Associated Complications: A Review.

Gossypetin, a flavonoid similar to quercetin, shows potential in treating type 2 diabetes and its complications. It has antioxidant, anti-inflammatory, and immunomodulatory properties that can protect organs from damage caused by diabetes.

Diabetes Hibiscus sabdariffa
Naidoo K and Khathi A (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242417609
PubMed:
38139436

Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.

Supplementing with myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc improved lipid profiles in T2DM patients without therapy modification, reducing cholesterol and LDL levels after 3 months and maintaining improvement after 6 months with weight reduction. (34 words)

Diabetes Gymnema sylvestre
Nani A et al (2023).
J Clin Med.
DOI:
10.3390/jcm12247650
PubMed:
38137721

Portulaca Oleracea L. (Purslane) Extract Protects Endothelial Function by Reducing Endoplasmic Reticulum Stress and Oxidative Stress through AMPK Activation in Diabetic Obese Mice.

Purslane, a food and drug, has various health benefits. This study found that it can improve endothelial function in diabetes by activating AMPK/eNOS signaling pathway, suggesting its potential in treating vascular complications.

DiabetesImmunologyObesity Portulaca oleracea
Miao L et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12122132
PubMed:
38136251
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