Hypoglycemic activity of Syzygium cumini (L.) Skeels seed extracts: an approach to in vitro, in vivo, and in silico studies.

Seed extracts were found to inhibit enzymes related to glucose metabolism and reduce blood glucose levels in rats. The acetone extract was most effective, and 1,2,3-Benzenetriol showed high affinity for human pancreatic α-amylase, indicating potential for managing diabetes.

Kavital A et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2268218

PubMed:

37819095

The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systematic review and dose-response meta-analysis of randomized controlled trials.

This meta-analysis of 24 randomized controlled trials found that cinnamon supplementation significantly reduced fasting blood sugar, insulin resistance, and hemoglobin A1C levels in patients with type 2 diabetes. Cinnamon may be an effective adjunct therapy for managing diabetes.

Moridpour AH et al (2024).

Phytother Res.

DOI:

10.1002/ptr.8026

PubMed:

37818728

Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review.

Nigella sativa (NS) has proven to effectively manage diabetes by improving glucose tolerance, reducing liver glucose production, balancing blood sugar and lipid levels, and stimulating insulin secretion. It counters oxidative stress and prevents diabetes onset and progression.

Shaukat A et al (2023).

Front Nutr.

DOI:

10.3389/fnut.2023.1126272

PubMed:

37818339

Phytochemical screening and anti-obesity, anti- diabetic and anti-oxidant properties of Scoparia dulcis leaf decoction (crude).

Researchers found bioactive compounds in porridge made from S. dulcis leaf essence that interact with proteins related to diabetes, oxidation, and obesity. Further analysis is required.

Mary AC et al (2023).

Bioinformation.

DOI:

10.6026/97320630019238

PubMed:

37808375

Characterization of the structure, antioxidant activity and hypoglycemic activity of soy (Glycine max L.) protein hydrolysates.

A study hydrolyzed soy isolate protein with five enzymes and evaluated their effects. The alcalase hydrolysate showed the highest potential in terms of antioxidant and hypoglycemic activities. It also had the greatest biological activities overall.

Xu Y et al (2023).

Food Res Int.

DOI:

10.1016/j.foodres.2023.113473

PubMed:

37803796

Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats.

Combining purslane, chard, and chicory leaf extracts improved glucose control in diabetic rats, restoring liver and pancreas health. This could lead to the development of natural drugs for diabetes.

Helmy SA et al (2023).

J Med Food.

DOI:

10.1089/jmf.2022.0119

PubMed:

37801671

Electrospun polyvinyl alcohol/Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers.

Researchers developed a multifunctional composite using tadalafil-loaded nanoparticles (NPs) and ashwagandha extract in nanofibers. It improved wound closure, reduced inflammation, and enhanced angiogenesis in diabetic rats, offering potential as a diabetic wound dressing.

Elsherbini AM et al (2023).

Nanomedicine (Lond).

DOI:

10.2217/nnm-2023-0127

PubMed:

37800462

In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.

Hou B et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117281

PubMed:

37797872