Diabetes Studies

Antidiabetic and antihyperlipidemic activities of Phyllanthus emblica L. extract in vitro and the regulation of Akt phosphorylation, gluconeogenesis, and peroxisome proliferator-activated receptor α in streptozotocin-induced diabetic mice.

Researchers investigated the potential benefits of L. fruits in diabetes and hyperlipidemia management. The study highlights the need for a safe and efficient drug for these conditions.

Huang SM et al (2023).
Food Nutr Res.
PubMed:
37850072

Impact of a retrograded starch ingredient obtained from Negro Jamapa beans (Phaseolus vulgaris L. Negro Jamapa) on glucose metabolism and oxidative stress in induced diabetic lab rats model.

Retrograded starch from Negro Jamapa beans reduced digestible starch, improved glucose levels, reduced hyperglycemia, improved weight gain, and reduced insulin resistance in diabetic animals.

Diéguez TS et al (2023).
Int J Biol Macromol.
PubMed:
37844824

Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism.

Michx. polysaccharide (RLP), from Chinese herbal medicine, reduces kidney damage, inflammation, and oxidative stress in DN mice. RLP modulates metabolism and inhibits apoptosis, suggesting it as a potential treatment for DN.

Zhang T et al (2023).
J Diabetes Res.
PubMed:
37840577

The effect of Abelmoschus esculentus L. (Okra) extract supplementation on glycemic control, inflammation, kidney function, and expression of PPAR-α, PPAR-γ, TGF-β, and Nrf-2 genes in patients with diabetic nephropathy: A triple-blinded, randomized, placebo-controlled trial.

This study found that okra extract supplementation did not have significant effects on kidney function, glycemic control, inflammation, or gene expression in patients with diabetic nephropathy. The results suggest that okra extract may not be an effective treatment for DN.

Nikpayam O et al (2023).
Br J Nutr.
PubMed:
37840235

The Effect of Lavandula stoechas on Wound Healing in an Experimental Diabetes Model.

This study investigates the effect of Lavandula stoechas on wound healing in a diabetes model. Understanding this effect could help improve treatment for diabetic foot, a dangerous complication of diabetes with various negative impacts.

Demir D et al (2023).
Cureus.
PubMed:
37829966

Oxidative stress in liver of streptozotocin-induced diabetic mice fed a high-fat diet: A treatment role of Artemisia annua L.

Artemisia annua extracts improved liver function and reduced oxidative stress in diabetic mice, showing comparable or greater antioxidant activity than metformin.

Ghanbari M et al (2023).
Endocr Regul.
PubMed:
37823572

The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction.

A mixture of Sclerocarya birrea, Nauclea latifolia, and Piper longum (SNP) improved blood glucose levels, protected neurons, and improved memory in diabetic rats by reducing oxidative stress, inflammation, and acetylcholinesterase activity.

Tientcheu JPD et al (2023).
Metab Brain Dis.
PubMed:
37821784