Dietary Consumption on Glycemic Control Among Prediabetes: A Review of the Literature.

Thipsawat S et al (2023).

SAGE Open Nurs.

DOI:

10.1177/23779608231218189

PubMed:

38130469

Hypoglycemic effect and intestinal transport of phenolics-rich extract from digested mulberry leaves in Caco-2/insulin-resistant HepG2 co-culture model.

Phenolics in mulberry leaves inhibit sugar digestion and uptake, regulate glucose metabolism, and improve glucose metabolism. Luteoforol and p-coumaric acid are the primary phenolics responsible for the hypoglycemic effect. They can be used as dietary supplements to regulate glucose metabolism.

Zhao Q et al (2024).

Food Res Int.

DOI:

10.1016/j.foodres.2023.113689

PubMed:

38129030

Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats.

Thymoquinone (ThyQ) from seeds reduces obesity, lowers blood glucose and insulin, improves glucose tolerance, and enhances insulin sensitivity. It also reduces liver damage markers, increases adiponectin levels, and regulates gene expression. ThyQ may be a useful treatment for obesity and related conditions.

Ramineedu K et al (2024).

3 Biotech.

DOI:

10.1007/s13205-023-03847-x

PubMed:

38125651

Computational analysis of potential drug-like compounds from Solanum torvum - A promising phytotherapeutics approach for the treatment of diabetes.

Scientists studied a medicinal plant called STV to find natural compounds that can treat diabetes. They found that chlorogenin and rutin, derived from STV, have strong binding affinities to key enzymes involved in glucose metabolism. These compounds may be potential natural therapeutic agents for diabetes management.

Choudhury AA and V DR (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2293279

PubMed:

38116744

Mechanistic role of Syzygium cumini (L.) Skeels in glycation induced diabetic nephropathy via RAGE-NF-κB pathway and extracellular proteins modifications: A molecular approach.

Researchers investigated the molecular mechanism of Syzygium cumini's interaction with the AGEs-RAGE-NF-κB pathway. This ancient medicinal plant may be beneficial in treating diabetic nephropathy due to its anti-glycemic, anti-glycation, anti-inflammatory, and antioxidant properties.

Apte MM, Khattar E and Tupe RS (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117573

PubMed:

38110133

Lead optimization of Allium sativum L. compounds for PTP1B inhibition in diabetes treatment: in silico molecular docking and dynamics simulation.

This study investigated how natural compounds bind to PTP1B, a drug target for diabetes. The optimized compounds had good binding scores and the kaempferol compounds showed stability. The study identified potential targets and pathways for anti-PTP1B effects, aiding diabetes medication development.

Ojo OA et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2294179

PubMed:

38109128

Saponins from Momordica charantia exert hypoglycemic effect in diabetic mice by multiple pathways.

Saponins from L. were tested on diabetic mice. Results: MCS reduced glucose levels, improved antioxidant capacity, decreased lipid levels, and repaired pancreatic cells. Implications: MCS has potential as an antidiabetic treatment.

Deng Y et al (2023).

Food Sci Nutr.

DOI:

10.1002/fsn3.3682

PubMed:

38107145

Unlocking the anti-diabetic potential of Gymnema sylvestre, Trigonella foenum-graecum, and their combination thereof: An in-vivo evaluation.

This study found that extracts from two plants improved blood glucose levels, insulin secretion, and restored serum parameters in diabetic rabbits. These plants may have potential as an alternative treatment for diabetes.

Kashif M et al (2023).

Food Sci Nutr.

DOI:

10.1002/fsn3.3685

PubMed:

38107140