Diabetes Studies

Phenolics Extracted from Jasminum sambac Mitigates Diabetic Cardiomyopathy by Modulating Oxidative Stress, Apoptotic Mediators and the Nfr-2/HO-1 Pathway in Alloxan-Induced Diabetic Rats.

Phenolic acids extracted from leaves improved cardiac function and reduced complications of diabetes-induced cardiomyopathy in rats, suggesting potential therapeutic effects against diabetes-related heart problems.

Umar U et al (2023).
Molecules.
PubMed:
37513325

Phytofabrication of Selenium Nanoparticles with Moringa oleifera (MO-SeNPs) and Exploring Its Antioxidant and Antidiabetic Potential.

This study synthesized selenium nanoparticles using a plant extract, which showed high purity, antioxidant properties (DPPH scavenging activity), and potential as an antidiabetic agent (inhibiting α-amylase and α-glucosidase enzymes). The plant extract could be a promising source for nanoparticle synthesis with biomedical applications.

Ahamad Tarmizi AA et al (2023).
Molecules.
PubMed:
37513196

Comparative Antihyperglycemic and Antihyperlipidemic Effects of Lawsone Methyl Ether and Lawsone in Nicotinamide-Streptozotocin-Induced Diabetic Rats.

Lawsone methyl ether (LME) and lawsone have strong inhibitory effects on α-glucosidase. In diabetic rats, LME reduces blood glucose, HbA1c, cholesterol, and more, making it a potential option for drug development.

Khan M et al (2023).
Metabolites.
PubMed:
37512570

Anti-Helicobacter pylori, Antioxidant, Antidiabetic, and Anti-Alzheimer's Activities of Laurel Leaf Extract Treated by Moist Heat and Molecular Docking of Its Flavonoid Constituent, Naringenin, against Acetylcholinesterase and Butyrylcholinesterase.

This study found that moist heat treatment of laurel leaf extract increases the concentration of certain beneficial compounds and enhances its antioxidant, anti-diabetic, and anti-Alzheimer's activities.

Al-Rajhi AMH et al (2023).
Life (Basel).
PubMed:
37511887

Mechanism of Anti-Diabetic Activity from Sweet Potato (Ipomoea batatas): A Systematic Review.

This study reviewed the compounds in sweet potatoes that contribute to their anti-diabetic activity. Four varieties were identified as having potential anti-diabetic properties. Phenolic acids, flavonols, flavanones, and anthocyanidins are responsible for this activity. The study suggests that sweet potatoes could be effective in treating type 2 diabetes.

Arisanti CIS et al (2023).
Foods.
PubMed:
37509903

Clinical efficacy and safety of okra (Abelmoschus esculentus (L.) Moench) in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial.

This clinical trial examines the effectiveness and safety of okra pod capsules as a treatment for type 2 diabetes and its potential anti-inflammatory effects.

Tavakolizadeh M et al (2023).
Acta Diabetol.
PubMed:
37507536

Total flavonoids of Hippophae rhamnoides L. improves type 2 diabetes symptoms in rats through down-regulating of the DAG/PRKCA/MAPK10/p65/TNF-α signalling pathway.

This study investigates the chemical features, active ingredients, and anti-diabetes mechanism of Hippophae rhamnoides fruit. Results provide insights for its traditional use in diabetes treatment.

Yang X et al (2023).
J Ethnopharmacol.
PubMed:
37499844