Diabetes Studies

Potato consumption, polygenic scores, and incident type 2 diabetes: An observational study.

Consuming total potatoes, mashed potatoes, and fried potatoes is associated with an increased risk of type 2 diabetes, independent of genetic predisposition. Replacing potatoes with non-starchy vegetables lowers risk.

Diabetes Solanum tuberosum
Wan X et al (2023).
Food Res Int.
DOI:
10.1016/j.foodres.2023.112936
PubMed:
37316042

Hippocampal proteins discovery of Panax quinquefolius and Acorus gramineus ameliorating cognitive impairment in diabetic rats.

Identifying diabetic cognitive impairment (DCI) early and finding effective treatments can delay or prevent irreversible dementia.

DiabetesNeuroscience Panax quinquefolius
Huan S et al (2023).
Psychopharmacology (Berl).
DOI:
10.1007/s00213-023-06393-9
PubMed:
37306736

Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes.

This study investigated the impact of endurance training and nettle leaf extract on liver pathways affected by diabetes in rats.

Diabetes Urtica dioica
Haghshenas R et al (2023).
Front Endocrinol (Lausanne).
DOI:
10.3389/fendo.2023.1071424
PubMed:
37305057

Anti-Hyperglycemic and Hypoglycemic Activities of 80% Methanol Extract and Solvent Fractions of Ocimum lamiifolium Hochst Ex Benth. (Lamiaceae) Leaves in Mice.

This study investigated the effects of Hochst ex Benth leaves in treating diabetes mellitus. Traditional medicine may provide affordable and safe alternative treatments for diabetes.

Diabetes Ocimum lamiifolium
Tesfaye T et al (2023).
J Exp Pharmacol.
DOI:
10.2147/JEP.S409997
PubMed:
37304205

Annona muricate Extract Supplementation Contributes to Improve Aberrant Multi-Organ Energy Metabolism via Muscle-Brain Connectivity in Diabetic Mice.

This study investigated the effects of AM extract on the energy metabolism of T2DM mice. The extract increased insulin signaling in the skeletal muscle and hippocampus, and increased levels of myokines and neurotrophic factors. This suggests that AME may be a potential nutraceutical for improving energy metabolism and muscle-brain connectivity in T2DM.

DiabetesNeuroscience Annona muricata
Lee H, Kim SY and Lim Y (2023).
Nutrients.
DOI:
10.3390/nu15112559
PubMed:
37299522

Insights on the Hypoglycemic Potential of Crocus sativus Tepal Polyphenols: An In Vitro and In Silico Study.

Saffron tepals have stronger anti-diabetic effects than stigmas. They inhibit carbohydrate digestion enzymes and glucose absorption, potentially preventing or managing diabetes.

Diabetes Crocus sativus
Bellachioma L et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24119213
PubMed:
37298165

Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats.

Portulaca oleracea and Metformin improve cognitive function and reduce inflammation and oxidative stress in diabetic rats, suggesting their potential for addressing cognitive decline and hippocampal changes associated with diabetes. The AMPK pathway is identified as a key mediator, while Portulaca oleracea may have additional non-AMPK dependent actions.

DiabetesImmunologyNeuroscience Portulaca oleracea
Hassan SF et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105566
PubMed:
37295752

Whole Grain Proso Millet (Panicum miliaceum L.) Attenuates Hyperglycemia in Type 2 Diabetic Mice: Involvement of miRNA Profile.

Whole grain proso millet supplementation reduced blood glucose and lipid levels, improved organ health, and inhibited genes related to gluconeogenesis in mice with type 2 diabetes. The study suggests that millet can be used as a dietary supplement to alleviate this condition.

Diabetes Panicum miliaceum
Deng X et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c08184
PubMed:
37294881
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