Gastroenterology Studies

Green synthesized silver nanoparticles using the plant-based reducing agent Matricaria chamomilla induce cell death in colorectal cancer cells.

Researchers used chamomile to synthesize silver nanoparticles (SNs) with anticancer properties, providing a safe and natural alternative to chemotherapy. This could potentially reduce side effects and offer a more affordable and eco-friendly treatment option for cancer.

Abdellatif AAH et al (2023).
Eur Rev Med Pharmacol Sci.
PubMed:
37916381

Jute (Corchorus olitorius L.) Nanocrystalline Cellulose Inhibits Insect Virus via Gut Microbiota and Metabolism.

JNCC reduced virus levels, improved gut health, increased beneficial gut bacteria, promoted antimicrobial peptides, and activated signaling pathways against the virus in honey bees. Potential antiviral agent.

Deng Y et al (2023).
ACS Nano.
PubMed:
37906569

Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota-gut-brain axis in corticosterone combined with chronic restraint stress-induced mice.

The researchers investigated how a traditional herbal formula called Zhi Zi Chi decoction (ZZCD) regulates the microbiota-gut-brain axis in treating anxious depression. Understanding these mechanisms could lead to improved treatments for neuropsychiatric disorders.

Tian X et al (2023).
CNS Neurosci Ther.
PubMed:
37905694

Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells.

Researchers developed a nanoformulation of costunolide (COST) to improve its anti-proliferative effects in colon cancer cells. The optimized formulation showed increased cytotoxicity, enhanced apoptosis, and altered gene expression compared to raw COST, making it more effective in killing cancer cells.

Alamoudi AJ et al (2023).
Biomed Pharmacother.
PubMed:
37897972

Phellinus igniarius Polysaccharides Ameliorate Hyperglycemia by Modulating the Composition of the Gut Microbiota and Their Metabolites in Diabetic Mice.

Researchers found that polysaccharides improved hyperglycemia symptoms, restored gut microbiota balance, and altered metabolic pathways in mice with type 2 diabetes, suggesting potential benefits for diabetes management.

Ni Z et al (2023).
Molecules.
PubMed:
37894615