Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome.

TCM can influence the gut microbiome to combat osteoporosis. This is because the gut microbiome affects inflammation, hormone levels, nutrient absorption, and bone mass. TCM herbs can regulate the gut microbiome and indirectly impact bone health. Puerarin specifically improves intestinal health and reduces inflammation caused by estrogen deficiency.

Li K et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500866

PubMed:

37884447

Tripterygium hypoglaucum extract ameliorates adjuvant-induced arthritis in mice through the gut microbiota.

Hu J et al (2023).

Chin J Nat Med.

DOI:

10.1016/S1875-5364(23)60466-2

PubMed:

37879792

Integrated network pharmacology and metabolomics to investigate the effects and possible mechanisms of Dehydroevodiamine against ethanol-induced gastric ulcers.

Researchers investigated the effect of dehydroevodiamine (DHE), a compound found in traditional Chinese medicine Tetradium ruticarpum, on ethanol-induced gastric ulcers. DHE has previously shown anti-inflammatory, analgesic, and antioxidant effects. Understanding its impact on gastric ulcers may have implications for treating such conditions.

Wang X et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117340

PubMed:

37879508

Understanding apoptotic induction by Sargentodoxa cuneata-Patrinia villosa herb pair via PI3K/AKT/mTOR signalling in colorectal cancer cells using network pharmacology and cellular studies.

This study investigated the specific anticancer ingredients and mechanism of action of Sargentodoxa cuneata and Patrinia villosa in combination for colorectal cancer treatment. Results could provide insights for developing effective therapies.

Mu BX et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117342

PubMed:

37879505

Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.

Demethylzeylasteral, a natural compound derived from Tripterygium wilfordii, has shown potent anti-colon cancer activity. This study identifies S100A11 as a target protein and NF-κB as a regulator of S100A11 expression, highlighting the potential of demethylzeylasteral for anti-tumor therapy.

Li W et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115725

PubMed:

37879212

Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer.

Researchers discovered that a compound called berberrubine, found in Coptis chinensis, selectively inhibits IMPDH2, a protein highly expressed in colorectal cancer. Berberrubine impairs cancer cell growth and reduces tumor size in cells and mouse models, indicating potential for CRC treatment.

He X et al (2023).

Biochem Pharmacol.

DOI:

10.1016/j.bcp.2023.115868

PubMed:

37871880

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Scientists found that morusinol, a compound from L., has potential as an anticancer agent for colorectal cancer. It inhibits cell growth, promotes cell death, and induces autophagy in cancer cells by affecting cholesterol metabolism. Animal models confirmed its ability to impede tumor growth, making it a potential candidate for CRC treatment.

Zhang X et al (2023).

J Agric Food Chem.

DOI:

10.1021/acs.jafc.3c01244

PubMed:

37870273

Phytochemical analysis and gastroprotective effect of Stellaria media (L.) Vill. methanolic extract on piroxicam-induced gastric ulcer in Wistar rats.

Aleem A et al (2023).

Pak J Pharm Sci.

PubMed:

37869918