Gastroenterology Studies

Characterization of metabolites from milk thistle flavonolignans generated by human fecal microbiota.

Scientists studied the biotransformation of milk thistle flavonolignans by gut microorganisms. They identified metabolites and potential pharmacological activities. This information is important for understanding the oral bioavailability and potential health benefits of milk thistle.

Pferschy-Wenzig EM et al (2023).
Phytochemistry.
PubMed:
37648045

Therapeutic potential of Litsea cubeba essential oil in modulating inflammation and the gut microbiome.

LCEO, an essential oil, protects the colon, reduces inflammation, and affects gut microbiome composition. It shows potential as a natural treatment for intestinal inflammation, impacting gut health.

Xia L et al (2023).
Front Microbiol.
PubMed:
37645231

RNA Sequencing and Bioinformatics Analysis Reveals the Downregulation of DNA Replication Genes by Morindone in Colorectal Cancer Cells.

Morindone, a natural compound, shows promise as a treatment for colorectal cancer (CRC). It downregulates genes involved in DNA replication and cell development. GINS2 is identified as a potential target. Validation confirms these findings. Consider using morindone for CRC treatment.

Chee CW et al (2023).
Appl Biochem Biotechnol.
PubMed:
37642925

Compound chenpi tea consumption reduces obesity-related metabolic disorders by modulating gut microbiota and serum metabolites in mice.

Scientists studied the anti-obesity effect of chenpi tea, made from citri reticulatae pericarpium, Ganoderma lucidum, and pu-erh tea, in mice on a high-fat diet. They used RNA sequencing and metabolomic analysis to identify potential mechanisms.

Wang J et al (2024).
J Sci Food Agric.
PubMed:
37638783