Gastroenterology Studies

Mollugin suppresses proliferation and drives ferroptosis of colorectal cancer cells through inhibition of insulin-like growth factor 2 mRNA binding protein 3/glutathione peroxidase 4 axis.

Mollugin, a compound from Rubia cordifolia, induces ferroptosis in colorectal cancer (CRC) cells by reducing GSH and increasing ROS, Fe, and MDA levels. Inhibition of ferroptosis reverses the antitumor effects of mollugin. High expression of IGF2BP3 in CRC suggests poor prognosis. Mollugin may be a promising CRC therapy by targeting the IGF2BP3/GPX4 axis.

Wang W et al (2023).
Biomed Pharmacother.
PubMed:
37677963

Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: Involvement of Nrf2/HO-1 and HMGB-1/NF-κB trajectories.

This study explores the use of onion (Allium cepa L.) for its anti-inflammatory and antioxidant properties in traditional medicine, particularly in treating gastric ulcers. Consider incorporating onion in your lab's research on natural remedies for various ailments.

Ali NB et al (2023).
J Ethnopharmacol.
PubMed:
37659760

Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS.

The study found that a herbal melanin derived from Nigella sativa upregulated the TLR4 receptor, increased COX-2 expression, and promoted the secretion of PGE2 and IL-6 in AGS cells. This suggests that the melanin may have gastroprotective effects and potential benefits for gastric prevention and treatment.

El-Obeid A et al (2023).
BMC Complement Med Ther.
PubMed:
37658354