Gastroenterology Studies

Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof.

The drug combination of Aiton (Kushen) and Franch. (Huanglian) is used to treat laxation. This study focused on their potential anti-cancer effects against colorectal cancer. The research found that a 1:1 ratio of Kushen and Huanglian had the best anti-cancer effect. The active components, matrine and berberine, were evaluated and found to reduce the growth of colorectal cancer in mice. Additionally, the combination of matrine and berberine showed better efficacy than using them alone. The study also identified and quantified the chemical constituents of the drug pair. The findings suggest that the combination of matrine and berberine could inhibit colorectal cancer by improving intestinal microbiota and regulating a signaling pathway.

Chen Z et al (2023).
Front Oncol.
PubMed:
37404762

Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.

Isoalantolactone (LAT) found in Elecampane can alleviate symptoms of depression in mice, showing potential as an alternative treatment for the condition.

Wang S et al (2023).
Psychopharmacology (Berl).
PubMed:
37400661