Immunology Studies

The Garlic Compound, Diallyl Trisulfide, Attenuates Benzo[a]Pyrene-Induced Precancerous Effect through Its Antioxidant Effect, AhR Inhibition, and Increased DNA Repair in Human Breast Epithelial Cells.

Exposure to B[a]P increases breast cancer risk. Garlic compound DATS can block B[a]P-induced carcinogenesis in breast cells, reducing cell damage and promoting DNA repair. DATS has potential for breast cancer prevention.

Ferguson DT et al (2024).
Nutrients.
PubMed:
38276538

Indian Almond (Terminalia catappa Linn.) Leaf Extract Extends Lifespan by Improving Lipid Metabolism and Antioxidant Activity Dependent on AMPK Signaling Pathway in Caenorhabditis elegans under High-Glucose-Diet Conditions.

Indian almond leaf extract (TCE) with high flavonoid and phenolic content showed antioxidant and antiaging effects in obese worms. TCE inhibited lipid and reactive oxygen species (ROS) accumulation and prolonged lifespan by downregulating atgl-1, daf-16, and skn-1 genes. TCE may have potential for antiaging under metabolic disorders.

Kim Y et al (2023).
Antioxidants (Basel).
PubMed:
38275634

Ganoderma lucidum polysaccharide hydrogel accelerates diabetic wound healing by regulating macrophage polarization.

Researchers developed a hydrogel using Ganoderma lucidum polysaccharide, sodium alginate, and carboxymethyl chitosan. The hydrogel improves wound healing in diabetic patients by promoting macrophage polarization, reducing inflammation, and enhancing tissue regeneration.

Li F et al (2024).
Int J Biol Macromol.
PubMed:
38266851

Ultrasound-assisted ethanol/K(2) HPO(4) aqueous two-phase extraction of polysaccharides from Plantago asiatica L. seeds: Process optimization, physicochemical properties, and antioxidant activity.

Zhang H and Zhu W (2024).
Phytochem Anal.
PubMed:
38263361

Predicting and optimizing reactive oxygen species metabolism in Punica granatum L. through machine learning: role of exogenous GABA on antioxidant enzyme activity under drought and salinity stress.

This study used machine learning models to predict the effects of gamma-aminobutyric acid (GABA) on plant traits during drought, salinity, and combined stress conditions. These findings could help enhance crop tolerance to stress factors, benefiting food security.

Zarbakhsh S et al (2024).
BMC Plant Biol.
PubMed:
38263036