Immunology Studies

Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations.

Researchers studied the potential of celery seed extract to prevent indomethacin-induced stomach ulcers in rats. This may lead to a new treatment or prevention approach for gastric ulcers.

Abu-Baih DH et al (2024).
BMC Complement Med Ther.
PubMed:
38355510

Molecular mechanisms of macrophage immunomodulation mediated by Areca inflorescence polysaccharides based on RNA-seq analysis.

Areca inflorescence polysaccharide (AFP2a) activates macrophages and promotes immune responses through signaling pathways, revealing its potential as a natural immunomodulator.

Chen D et al (2024).
Int J Biol Macromol.
PubMed:
38354932

Humulus lupulus aqueous extract and hydrolate as a potential ingredient for cosmetics: Chemical characterization and in vitro antimicrobial, cytotoxicity, antioxidant, and anti-inflammatory assessment.

Humulus lupulus extracts contain various molecules with antimicrobial, antioxidant, and anti-inflammatory properties, such as polyphenols, α-acids, β-acids, and hydrocarbons. Understanding these components helps harness the plant's medicinal benefits.

Valente J et al (2024).
Fitoterapia.
PubMed:
38354824

Preparation and in vivo evaluation of nano sized cubosomal dispersion loaded with Ruta graveolens extracts as a novel approach to reduce asthma-mediated lung inflammation.

Study finds extract with anti-asthmatic effects, reducing symptoms and improving lung function in rats. Extract shows antioxidant, anti-inflammatory activities and induces autophagy while inhibiting apoptosis. Could be developed as anti-allergic asthma drug.

Alyami MH et al (2024).
Saudi Pharm J.
PubMed:
38352238

Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats.

Citrus reticulata peel extract (CPE) was found to have potent antioxidant activity and can alleviate abamectin-induced liver toxicity by modulating various parameters. This suggests that CPE could be effective in reducing the harmful effects of abamectin exposure.

Rahib A et al (2024).
Tissue Cell.
PubMed:
38350206

n-Butanol fraction of moringa seed attenuates arsenic intoxication by regulating the uterine inflammatory and apoptotic pathways.

Researchers found that the n-butanol fraction of Moringa oleifera seed (NB) effectively repaired uterine damage caused by arsenic poisoning. NB reduced lipid peroxidation, increased antioxidant enzyme activity, restored uterine histomorphology, and normalized mRNA and protein expression of inflammatory and apoptotic indicators. The interaction between glucomoringin and methyl glucosinolate may limit caspase-3 activity, making NB a potential therapy for arsenic-induced uterine damage.

Jana S et al (2024).
Environ Sci Pollut Res Int.
PubMed:
38349492

COP-22 Alleviates D-Galactose-Induced Brain Aging by Attenuating Oxidative Stress, Inflammation, and Apoptosis in Mice.

COP-22, a curcumin derivative, shows potential in protecting the brain from aging-induced damage by reducing oxidative stress, improving cholinergic system dysfunction, and protecting nerve cells. It also demonstrates the ability to reduce oxidative stress in the liver and kidney. It could be used in aging therapy and to treat diseases like Alzheimer's.

Ma Y et al (2024).
Mol Neurobiol.
PubMed:
38347285

Liposomal formulations of Oleae europaea L.: analyzing the antioxidant and antidiabetic activities along with toxicity profile in pancreatic beta TC6 cell line.

A study characterized a plant extract with strong antioxidant and antidiabetic properties. They prepared nanoformulations of the extract and tested their activities. The encapsulation efficiency was high, and the formulations exhibited antioxidant and antidiabetic activity.

Köngül Şafak E et al (2024).
Int J Environ Health Res.
PubMed:
38344812