The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial.

In this study, researchers investigated the effects of spinach supplementation and a hypocaloric diet on women with polycystic ovary syndrome (PCOS). They found that this intervention improved gut health, neurotrophic factor levels, and oxidative stress in PCOS patients.

Nikrad N et al (2023).

J Ovarian Res.

DOI:

10.1186/s13048-023-01288-x

PubMed:

37968684

New Monoterpenoid Indole Hybrids from Gelsemium elegans with Anti-Inflammatory and Osteoclast Inhibitory Activities.

Researchers discovered two new alkaloids, along with six known analogues, in Gelsemium elegans. These compounds showed anti-inflammatory activity and inhibited osteoclast formation, suggesting potential therapeutic applications for G. elegans.

Zhang PP et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202301665

PubMed:

37968250

OPHTHALMIC WILD OLIVE (ACEBUCHE) OIL NANOEMULSIONS EXERT OCULOPROTECTIVE EFFECTS AGAINST OXIDATIVE STRESS INDUCED BY ARTERIAL HYPERTENSION.

Scientists developed an olive oil-based formulation for ocular administration to counteract oxidative damage in hypertensive eye diseases. The formulation, tested in mice, reduced morphological alterations and demonstrated antioxidant effects, making it a promising therapy for ocular pathologies associated with hypertension.

Santana-Garrido A et al (2023).

Int J Pharm.

DOI:

10.1016/j.ijpharm.2023.123602

PubMed:

37967686

Gastrodia elata specific miRNA attenuates neuroinflammation via modulating NF-κB signaling pathway.

Gas-miR2-3p, derived from oral administration, reduces inflammatory factors TNF-α, IL-6, and IL-1β in both cells and animals. It also downregulates p-p65 and p-IκBα, alleviating neuroinflammation by modulating the NF-κB signaling pathway. MiRNAs have potential as novel regulators for neuroinflammation.

Fu J et al (2023).

Int J Neurosci.

DOI:

10.1080/00207454.2023.2280835

PubMed:

37965801

Pleiotropic effects of Mentha longifolia L. extract on the regulation of genes involved in inflammation and apoptosis induced by Clostridioides difficile ribotype 001.

This study investigates the potential of a hydroethanolic extract of L. to inhibit the growth of RT001 bacteria and its associated inflammation and cell death. Relevant for finding new medicines against multidrug-resistant infections.

Raeisi H et al (2023).

Front Microbiol.

DOI:

10.3389/fmicb.2023.1273094

PubMed:

37965560

Molecular Identification and Antioxidant Activity Determination among Coffee Varieties Cultivated in Nepal.

This study identified coffee samples from Nepal and measured their antioxidant activity and phenolic content. Roasting increases antioxidant activity but decreases phenolic content.

Pokharel S et al (2023).

ScientificWorldJournal.

DOI:

10.1155/2023/7744647

PubMed:

37964891

Allium sativum Essential Oil Supplementation Reverses the Hepatic Inflammation, Genotoxicity and Apoptotic Effects in Swiss Albino Mice Intoxicated with the Lead Nitrate.

Sharma K and Sharma V (2023).

Biol Trace Elem Res.

DOI:

10.1007/s12011-023-03924-5

PubMed:

37964042

Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter.

Jung SH et al (2023).

Nutrients.

DOI:

10.3390/nu15214599

PubMed:

37960252