Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT/NF-κB/ STAT3 pathway uncovered by single-cell RNA sequencing.

Researchers investigated the potential of S. officinalis as a treatment for UC, a serious and incurable illness causing bloody stools. Understanding its molecular mechanism and disease basis could lead to improved treatments with fewer side effects.

Li C et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155052

PubMed:

37717310

Zhizi-Chuanxiong herb pair alleviates atherosclerosis progression in ApoE(-/-) mice by promoting the methylation of FGFR3 to inhibit MAPK/ERK-mediated apoptosis.

Gardenia Fructus and Chuanxiong Rhizoma, traditional Chinese medicines, were studied for treating atherosclerosis. They were found to have vascular protective effects, detoxify and activate blood, with potential implications for new AS treatments.

Zhang Y et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117188

PubMed:

37716492

Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis.

Matrine, a compound from Sophora flavescens, causes liver injury by disrupting antioxidant pathways and inducing ferroptosis. This study shows that MT reduces cell viability, increases oxidative stress, and alters iron homeostasis. The cytotoxic effects can be reversed by ferroptosis inhibitors, Nrf2 agonists, or selenium supplementation.

Wang X et al (2023).

Chem Biol Interact.

DOI:

10.1016/j.cbi.2023.110713

PubMed:

37716422

Evaluating β-cryptoxanthin antioxidant properties against ROS-induced macromolecular damages and determining its photo-stability and in-vitro SPF.

The study found that β-cryptoxanthin, derived from Kocuria marina DAGII, is a potent antioxidant that can protect against damage caused by Reactive Oxygen Species (ROS). It can prevent lipid peroxidation, protein oxidation, and DNA damage. It also has UV protection capabilities.

Brahma D and Dutta D (2023).

World J Microbiol Biotechnol.

DOI:

10.1007/s11274-023-03747-5

PubMed:

37715879

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Zhang J et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117134

PubMed:

37714227

Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity.

Scientists discovered three new compounds, called andropanilides A-C, from a plant called Andrographis paniculata. Andropanilide A showed promising anti-inflammatory properties by reducing the expression of pro-inflammatory molecules. This research may lead to the development of new drugs to treat inflammation-related diseases.

Yu Y et al (2023).

Nat Prod Bioprospect.

DOI:

10.1007/s13659-023-00394-z

PubMed:

37713002

Toward Sustainable Wax Extraction from the Saccharum officinarum L. Filter Cake Byproduct: Process Optimization, Physicochemical Characterization, and Antioxidant Performance.

Researchers have identified an efficient method to extract valuable compounds from filter cake, offering potential applications in obtaining fatty alcohols and phytosterols. The optimized method preserved antioxidant activity, making it suitable for filter cake utilization.

Teixeira FS et al (2023).

ACS Sustain Chem Eng.

DOI:

10.1021/acssuschemeng.3c03279

PubMed:

37711765

Arbutus unedo fruit syrup as a fortifying agent: effect on physicochemical, microbiological, rheological, sensory and antioxidant properties of yoghurt.

This study evaluated the antioxidant and antibacterial activities of fruits and their syrup when incorporated into bi-layer yogurt. Results showed that both extracts had antibacterial effects and the syrup increased yogurt consistency. Fermentation improved antioxidant activity initially, but it decreased over time during storage.

Essaidi I et al (2023).

J Food Sci Technol.

DOI:

10.1007/s13197-023-05801-4

PubMed:

37711580