Phenolic Profiling, Antioxidant, and Antibacterial Activities of Selected Medicinal Plants from Tunisia.
- Hamrouni H et al (2023).
- Chem Biodivers.
- PubMed:
- 37369625
Research explores dysbiosis in gut microbiota, genetic, immunological, and environmental factors in ulcerative colitis & Crohn's disease. Medicinal plants/compounds regulate NLRP3 inflammasome & reduce inflammation, offering treatment potential. Clinical validation and effective treatments development necessary.
Researchers have developed a new approach for treating breast cancer using a compound called piperine (PIP). PIP has shown promise as a chemotherapeutic agent, but its toxicity has limited its use. To overcome this, the researchers created a nanotechnology-based treatment by encapsulating PIP within an organic metal-organic framework (MOF) called MIL-100(Fe). They further enhanced the treatment by coating the MOFs with macrophage membranes (MM) to improve immune system evasion. Through laboratory experiments, the researchers confirmed the successful synthesis of MM@PIP@MIL-100(Fe) nanoparticles and demonstrated their increased cytotoxicity against breast cancer cells compared to free PIP. This innovative approach shows potential for effective breast cancer therapy and warrants further exploration and optimization.
A traditional Mexican remedy, known for its anticancer properties, has been found to contain cadinane-type sesquiterpenes like 7-hydroxy-3,4-dihydrocadalene, which have shown cytotoxic effects. However, the exact mechanism of action and regulation of these agents on tumor cells remains unknown. In this study, the cytotoxic activity and mechanism of action of 7-hydroxy-3,4-dihydrocadalene and two semi-synthetic cadinanes derivatives were investigated for the first time on breast cancer cells. This research aims to shed light on the potential of these compounds in fighting breast cancer.
This study tested a polyherbal emulsion on diabetic rats and found that it reduced blood glucose and lipid levels, increased insulin, and protected pancreas and kidney tissues. It suggests that the formulation could be used as a remedy or alongside traditional diabetes medication.