Immunology Studies

Anti-inflammatory and memory-enhancing properties of Chinese herbal extracts: The possible application in Alzheimer's disease.

Chinese herbal extracts show promise in the treatment of Alzheimer's disease by improving memory and reducing inflammation. These extracts have potential for early AD treatment due to their fewer adverse effects and ease of consumption.

Varinthra P et al (2022).
Tzu Chi Med J.
PubMed:
37261298

Antioxidant capacity and cytotoxic effect of an optimized extract of isabella grape (Vitis labrusca) on breast cancer cells.

Isabella grapes contain phenolic compounds that have beneficial effects on human health, including potential anti-breast cancer properties. A study conducted in Colombia used ultrasound-assisted extraction to obtain a crude extract with antioxidant properties and high polyphenol content. The extract induced a decrease in the viability of breast cancer cells by affecting mitochondrial function and increasing reactive oxygen species. Molecular docking simulations also suggested that the phenolic compounds could interact with proteins involved in apoptosis. These findings highlight the potential of Isabella grape phenolic compounds as adjuvant chemopreventive agents for breast cancer treatment.

Vélez MD et al (2023).
Heliyon.
PubMed:
37260897

Sanguisorba officinalis L. promotes diabetic wound healing in rats through inflammation response mediated by macrophage.

Chinese medicine Sanguisorba officinalis L. extract (ESO) accelerates diabetic wound healing by reducing inflammation through blocking NF-κB/NLRP3 signaling pathway. Promising treatment option.

Song J et al (2023).
Phytother Res.
PubMed:
37260161

Tanshinone IIA mediates protection from diabetes kidney disease by inhibiting oxidative stress induced pyroptosis.

Tanshinone IIA, found in Salvia miltiorrhiza, shows potential in delaying the progression of diabetes kidney disease, but further research is needed to understand how it works.

Wu Q et al (2023).
J Ethnopharmacol.
PubMed:
37257702

Eco-friendly green synthesis of silver nanoparticles from Aegle marmelos leaf extract and their antimicrobial, antioxidant, anticancer and photocatalytic degradation activity.

In this research, silver nanoparticles (Ag NPs) were synthesized using leaf extract as the reducing and capping agent. The formation of Ag NPs was confirmed by UV-vis spectrophotometry, and the nanoparticles had a spherical morphology with a size range of ∼30-50 nm. The synthesized Ag NPs exhibited potential anticancer, antimicrobial, and antioxidant activity, showing cytotoxicity against MDA-MB-231 breast cancer cells. Furthermore, the Ag NPs acted as an excellent photocatalyst, degrading environmentally polluted Basic Fuchsin dye in just 18 minutes. This research demonstrates the potential applications of green-synthesized Ag NPs in various fields.

Rama P et al (2023).
Heliyon.
PubMed:
37255978