Immunology Studies

Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2/ARE and PI3K/AKT Pathways.

Baicalin, found in Scutellaria baicalensis Georgi plant, has been shown to have kidney-protective properties. However, its impact on mesangial proliferative glomerulonephritis (MPGN) is not well understood. This study aimed to explore the effect of Baicalin on MPGN and uncover the mechanisms involved. By understanding how Baicalin affects MPGN, we can potentially develop new therapies for this prevalent form of primary glomerulonephritis.

Ning X et al (2023).
Discov Med.
PubMed:
37272104

Pinellia ternata (Thunb.) Breit. attenuates the allergic airway inflammation of cold asthma via inhibiting the activation of TLR4-medicated NF-kB and NLRP3 signaling pathway.

Pinellia ternata is effective against allergic airway inflammation, particularly in cold asthma, but its active ingredients and mechanism of action are still unclear.

Tao X et al (2023).
J Ethnopharmacol.
PubMed:
37268256

Withania somnifera inhibits photorefractoriness which triggers neuronal apoptosis in both pre-optic and paraventricular hypothalamic area of Coturnix coturnix japonica: involvement of oxidative stress induced p53 dependent Caspase-3 mediated low immunoreactivity of estrogen receptor alpha.

Study on quails reveals Withania somnifera root extract increases estrogen, decreases corticosterone, reduces neuronal apoptosis, and oxidative stress. Prolonged light exposure causes apoptosis and stress, but WS root extract reverses these effects through increased estrogen and ERα expression.

Baghel K, Niranjan MK and Srivastava R (2023).
Photochem Photobiol Sci.
PubMed:
37266906