Green Synthesis of Zinc Oxide Nanoparticles from Althaea officinalis Flower Extract Coated with Chitosan for Potential Healing Effects on Diabetic Wounds by Inhibiting TNF-α and IL-6/IL-1β Signaling Pathways.

Researchers developed eco-friendly wound healing formulations using ZnO-NPs and chitosan gel with antioxidant and antibacterial properties. This could help diabetic patients with chronic wounds heal faster and prevent complications like ulcers and gangrene.

Elhabal SF et al (2024).

Int J Nanomedicine.

DOI:

10.2147/IJN.S455270

PubMed:

38559447

A Nuphar lutea plant active ingredient, 6,6'-dihydroxythiobinupharidine, ameliorates kidney damage and inflammation in a mouse model of chronic kidney disease.

DTBN from Nuphar lutea reduces inflammation in CKD mice by inhibiting NF-κB. Improved renal function and inflammation indices suggest potential as a CKD treatment.

Landau D et al (2024).

Sci Rep.

DOI:

10.1038/s41598-024-58055-1

PubMed:

38555397

Triterpenoids and triterpenoid saponins from Vitex negundo and their anti-inflammatory activities.

Scientists isolated new compounds from Vitex negundo plant, determined structures by analysis. Vitnegundins A, E, and swinhoeic acid show potential for inhibiting inflammation. Consider for anti-inflammatory drug development.

Gu C et al (2024).

Phytochemistry.

DOI:

10.1016/j.phytochem.2024.114068

PubMed:

38554895

Mechanism of Nicotiflorin in San-Ye-Qing rhizome for anti-inflammatory effect in ulcerative colitis.

Ruan Y et al (2024).

Phytomedicine.

DOI:

10.1016/j.phymed.2024.155564

PubMed:

38554577

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.

23-HBA from P. chinensis inhibits M2 macrophage polarization, decreasing resistance to 5-FU in colorectal cancer. Suppresses IL-10/STAT3/Bcl-2 pathway, enhancing 5-FU efficacy and reducing M2 macrophage presence in tumor tissues.

Fan Z et al (2024).

Cancer Immunol Immunother.

DOI:

10.1007/s00262-024-03662-0

PubMed:

38554148

Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis.

Yang H et al (2024).

Arch Biochem Biophys.

DOI:

10.1016/j.abb.2024.109965

PubMed:

38552763

Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury.

Liu YG et al (2024).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2024.116456

PubMed:

38552441

Investigation of prunetrin induced G2/M cell cycle arrest and apoptosis via Akt/mTOR/MAPK pathways in hepatocellular carcinoma cells.

Abusaliya A et al (2024).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2024.116483

PubMed:

38552440