Immunology Studies

Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells.

Anthemis hyaline, Nigella sativa, and Citrus sinensis extracts show promise in inhibiting coronavirus replication. Nigella sativa increases IL-8 levels and gene expression changes. Anthemis hyaline extract is the most effective in reducing viral load.

Bostancıklıoğlu M, İğci M and Ulaşlı M (2024).
Gene.
PubMed:
38485035

Effect and mechanism of Prunella vulgaris L. extract on alleviating lipopolysaccharide-induced acute mastitis in protecting the blood-milk barrier and reducing inflammation.

P vulgaris may help treat mastitis, but evidence is lacking. Further research needed to validate its effectiveness and understand how it works.

Luo H et al (2024).
J Ethnopharmacol.
PubMed:
38484956

Pro-inflammatory enzyme inhibition of lipoxygenases by flavonoid rich extract from Artemisia vulgaris.

Artemisa vulgaris extract inhibits lipoxygenases, reducing inflammation. Optimal extraction conditions yield high flavonoid content. Extract acts as a non-competitive inhibitor, potentially binding to free or substrate-bound LOX.

Lim JR, Chua LS and Mustaffa AA (2024).
J Chromatogr B Analyt Technol Biomed Life Sci.
PubMed:
38484676

8-shogaol derived from dietary ginger alleviated acute and inflammatory pain by targeting TRPV1.

TL;DR: 8-Shogaol (8S) in ginger reduces inflammatory pain and morphine tolerance by activating TRPV1 channels. Potential new drug for pain relief.

Cheng XL et al (2024).
Phytomedicine.
PubMed:
38484627

Antibacterial and Antioxidant Efficacies of Secondary Metabolites from the Roots of Cyphostemma adenocaule: A Combined In Vitro and In Silico Study.

Study isolated compounds from plant traditionally used for medicinal purposes. Compounds showed potent antioxidant and antibacterial activities, with potential for drug development. Traditional medicine supported by scientific evidence.

Gebrehiwot H et al (2024).
J Trop Med.
PubMed:
38482509

Gypenoside induces apoptosis by inhibiting the PI3K/AKT/mTOR pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 in gastric cancer.

Gypenoside induces apoptosis in gastric cancer cells, inhibits PI3K/AKT/mTOR pathway, and reduces PD-L1 expression. Enhances antitumor immunity of T cells. Potential new therapeutic agent for immunotherapy in gastric cancer.

Wu H et al (2024).
Front Pharmacol.
PubMed:
38482051

Evaluation of Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Raspberry Fruit Extract: An In Vitro Study.

Raspberry extract has strong antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising natural remedy for oral health issues like mucosal lesions, cancer, and candidiasis. Additional studies are needed to confirm its potential benefits.

Gomathi R, Umamaheswari TN and Prethipa R (2024).
Cureus.
PubMed:
38481926

Comparative study of the quality indices, antioxidant substances, and mineral elements in different forms of cabbage.

Study analyzed 159 cabbage varieties for quality, antioxidants, and minerals; different forms/colors had varying content. Findings can help choose best cabbage types for health benefits.

Yue Z et al (2024).
BMC Plant Biol.
PubMed:
38481163