Neuroscience Studies

Isorhynchophylline ameliorates stress-induced emotional disorder and cognitive impairment with modulation of NMDA receptors.

Researchers investigated the effects of isorhynchophylline on stress-induced emotional disorders and cognitive impairment. They conducted experiments on mice, observing their cognitive abilities and emotional responses under stress. The study found that isorhynchophylline had positive effects on both emotional and cognitive functions, suggesting a potential therapeutic use for humans. Further studies should explore this possibility.

Neuroscience Uncaria rhynchophylla
Wang C et al (2022).
Front Neurosci.
DOI:
10.3389/fnins.2022.1071068
PubMed:
36590289

Inhibition of the TLR/NF-κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson's Disease.

Plumbagin, a molecule extracted from a medicinal herb, has been studied for its potential to treat Parkinson's disease (PD). This study found that plumbagin partially repairs the loss of dopaminergic neurons and improves behavioral impairment in mice with PD. It also inhibits inflammatory pathways and enhances autophagy. These results suggest that plumbagin has promise as a treatment agent for PD, but further studies are needed to confirm its effectiveness.

Neuroscience Plumbago zeylanica
Su Y et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/1837278
PubMed:
36589679

Effect of Hydroalcoholic Extract of Stachys lavandulifolia on Pentylenetetrazole-induced Seizures in Male Mice: The Role of GABAergic and Opioidergic Systems.

The study tested a traditional Iranian medicine for its anticonvulsant effects in male mice. The medicine was found to be effective against seizures induced by Pentylenetetrazole and worked through the benzodiazepine and opioid receptors. This research provides evidence for the potential of traditional medicines in treating epilepsy.

Neuroscience Stachys lavandulifolia
Behzadnia H et al (2022).
Basic Clin Neurosci.
DOI:
10.32598/bcn.2021.2299.1
PubMed:
36589024

Neuroprotective effects of the fractions of Ocimum basilicum in seizures induced by pentylenetetrazole in mice.

The study looked at the protective and antioxidant effects of a compound called against seizures induced by PTZ. The results suggest this compound may have potential as a treatment for seizure disorders.

Neuroscience Ocimum basilicum
Mansouri S et al (2022).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2022.20470
PubMed:
36583175

Computational screening for new neuroprotective ingredients against Alzheimer's disease from bilberry by cheminformatics approaches.

Researchers used advanced artificial intelligence models and target prediction methods to screen natural products for potential medicinal compounds to treat Alzheimer's disease (AD). They identified a new ingredient, Ma-3-gal-Cl, found in bilberries that showed significant effects on protecting cells from AD-related damage, decreasing intracellular ROS, maintaining mitochondrial membrane potential, reducing activated caspase-3, and inhibiting Aβ aggregation. These promising results suggest that natural products could be a valuable resource for drug discovery to treat AD.

Neuroscience Vaccinium myrtillus
Xiao R et al (2022).
Front Nutr.
DOI:
10.3389/fnut.2022.1061552
PubMed:
36570129

Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents.

Researchers synthesized four analogs of piperlongumine, an alkaloid found in Piper longum, and tested their anti-platelet aggregation activity. Compound 8 showed the strongest activity, so it was studied further and found to have good binding affinity to stroke-related protein targets. Animal experiments showed that compound 8 could significantly improve brain tissue damage after ischemia, potentially reducing injury from ischemic stroke by inhibiting apoptosis and structural disorders. This suggests piperlongumine analogs could be developed into treatments for ischemic stroke.

CardiologyNeuroscience Piper longum
Lijuan T et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105398
PubMed:
36563762

Screening of Monoamine Oxidase B Inhibitors from Fragaria nubicola by Ligand Fishing and Their Neuroprotective Effects.

Researchers investigated the health-promoting effects of Tibetan strawberry and identified two inhibitors that protect against neurodegenerative conditions. Using enzyme-functionalized magnetic nanoparticles coupled with UPLC-QTOF-MS, they identified quercetin-3---d-glucuronide-6″-methyl ester () and kaempferol-3---d-glucuronide-6″-methyl ester () with the IC values of 19.44 ± 1.17 and 22.63 ± 1.78 μM, respectively. Both compounds exhibited significant neuroprotective effects on 6-hydroxydopamine-induced PC12 cells. The study sheds light on the potential of functional food for developing neuroprotective compounds.

Neuroscience Fragaria nubicola
Hu YK et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.2c06630
PubMed:
36562659

Ligustroflavone exerts neuroprotective activity through suppression of NLRP1 inflammasome in ischaemic stroke mice.

Researchers investigated using LIG, a compound derived from an herbal plant, as a potential treatment for ischemic stroke. They established an ischaemic stroke model in mice and used various tests to assess neurological deficits. Treatment with LIG showed significant anti-inflammatory and neuroprotective activity by minimizing impairment of neurological function, blocking neuronal damage, and attenuating upregulation of inflammatory cytokines. Overall, the findings suggest the potential of LIG as a treatment for stroke by inhibiting NLRP1 inflammasome and reducing inflammation.

CardiologyNeuroscience Ligustrum lucidum
Bi F et al (2022).
Exp Ther Med.
DOI:
10.3892/etm.2022.11707
PubMed:
36561613
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