Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits.
- Jiang N et al (2023).
- Phytother Res.
- DOI:
- 10.1002/ptr.7627
- PubMed:
- 36608695
This study evaluated Traditional Chinese Medicine (TCM) for treating epilepsy. The efficacy and safety of TCM were tested. Results showed that TCM was effective and safe in treating epilepsy. This suggests that TCM could be a potential alternative treatment option for epilepsy patients.
Researchers analyzed the ethanol extract of Peggy Red and Green fig peel through LC-MS/MS to determine its phytochemical components and neuroprotective effects. They found 50 compounds including phenols, flavonoids, and anthocyanins with antioxidant properties. Peggy Red had higher antioxidant activity and was able to reduce toxicity in Alzheimer's transgenic CL4176 by decreasing the aggregation of amyloid-beta and increasing antioxidant enzyme activities. The results suggest the potential of Peggy Red peel extract as a new drug source against AD.
Phytochemical cucurbitacin E (CuE) may be a promising drug discovery treatment in Alzheimer's disease (AD). This study investigated CuE's effects on TAU fibril formation in okadaic acid-induced AD in rats. Results suggest that CuE contributes to memory gain by reducing TAU protein accumulation. Further evaluations in future preclinical and clinical studies are warranted.
A study tested the effects of extracts from Rosemary and Saffron, given individually and combined, on Alzheimer's neuroinflammation in rats. The rats were given extracts over 15 days and then tested for cognitive impairment, amyloid neuroproteins, oxidative stress, and other markers. The extracts showed significant improvement in all parameters compared to the control group and a better morphological appearance in the cortex and hippocampus. Computational analysis found the extracts may impede the activity of proteins regulating disease progression, suggesting these extracts could help treat Alzeheimer's.
The use of herbal medicines is increasing in popularity for their potential to develop effective medications with minimal harmful effects. Purslane has various applications in treating disorders such as arthritis, burns, coughs, and liver disorders, as well as shortness of breath. Research shows that purslane has qualities including neuroprotective, anti-inflammatory, and antioxidant properties. This study updated existing literature on purslane and found it has potential therapeutic effects for various nervous system disorders, including Alzheimer's disease, Parkinson's disease, depression, and anxiety. More research is needed to further support its beneficial effects on these disorders.
Researchers tested an herbal medication, standardized hydroethanolic extract of Citrus aurantium leaves, for its ability to treat depression in male rats experiencing chronic stress. The extract has been shown to have several beneficial effects on the central nervous system. The study aimed to understand the antidepressant activity of the extract, as few effective antidepressant medications without side effects exist. This study found that the extract was effective in improving depressive symptoms in rats under chronic stress. This suggests that the extract may be a promising candidate for further study as a potential antidepressant medication.
Arctigenin, a natural bioactive compound, was compared with matairesinol and trachelogenin in their effects on synaptic activity in rat brain slices. Arctigenin and trachelogenin were found to be more potent in inhibiting glutamate receptors and decreasing the amplitude of evoked potential early component in the rat brain than matairesinol. These results suggest that trachelogenin and arctigenin could be potential candidates for the development of neuroprotective drugs.