A Chinese medicinal herb called Gastrodia elata Blume is used to treat conditions such as headaches, epilepsy, and depression.
Researchers examined a case of a patient who presented with stroke-like symptoms, which were later attributed to SB toxicity. While SB toxicity is a rare cause of stroke mimic, this study emphasizes the importance of considering non-vascular conditions in cases of acute neurological deficits.
Scientists isolated and identified 22 compounds from the roots of Zanthoxylum bungeanum Maxim., including two previously unknown ones. They used various techniques to determine the chemical structures of the compounds and found that they had antioxidant properties. One of the compounds, number 18, protected nerve cells from damage.
Researchers investigated whether MP could reduce seizure severity and increase seizure control in a rat model of epilepsy. They administered the herb orally and found that it significantly decreased seizure severity and increased seizure control. This study suggests that MP may have therapeutic potential as an adjunctive therapy in managing epilepsy.
Researchers screened natural products to find small molecules that target voltage-gated sodium and calcium channels involved in pain processing. These findings are important as they could lead to alternative therapies for chronic pain, reducing dependence on opioids.
Researchers studied the effects of two traditional Chinese medicine plants, and found that both extracts improved short-term memory, mechanosensory response, and resistance to oxidative stress in a model organism. Chemical analyses showed the presence of bioactive compounds, including zingibroside R1, which was responsible for the observed health benefits of . A hydroxygallic acid derivative and sterol lipid were also present in the most bioactive fraction of , but hardly in . These findings suggest that has overall anti-aging effects on the model organism and provide insight into the specific components responsible.
Scientists obtained samwinol from traditional Chinese Tibetan medicine by chromatography separation and investigated its effects on protecting cells against neurotoxicity caused by amyloid beta protein fragment. The results showed that samwinol increased cell viability, inhibited the production of reactive oxygen species, and suppressed ERK/AKT phosphorylation while promoting Nrf2/HO-1 signaling. Samwinol has significant anti-neuroinflammatory and antioxidant activities, suggesting its potential use for treating Alzheimer's disease. Further studies are needed to confirm its efficacy.
This study investigated the neuroprotective effects of carnosic acid (extracted from Salvia rosmarinus) in an in vitro model of Alzheimer's disease (AD). Carnosic acid improved neuronal survival by suppressing apoptosis and restored synaptic impairments by increasing expression levels of brain-derived neurotrophic factor (BDNF), postsynaptic density protein-95 (PSD-95), and synaptophysin (Syn). These effects were dependent on inhibiting the phosphorylation of N-methyl-D-aspartate receptors (NMDARs) and its downstream cascades. Carnosic acid could potentially be a targeted candidate for the treatment of AD.