Neuroprotective Effects of the Ethanolic Leaf Extract of Crassocephalum crepidioides (Asteracaeae) on Diazepam-Induced Amnesia in Mice.
- Galba Jean B et al (2022).
- Adv Pharmacol Pharm Sci.
- DOI:
- 10.1155/2022/1919469
- PubMed:
- 36212180
This study explored how tea infusions affect the brain health of rats. Twenty-four rats were divided into four groups, with one serving as a control. The test groups received either root, leaf, or a combination of both infusions orally for one week. Results showed that the infusions decreased levels of harmful compounds in the rats' brain tissue and increased levels of beneficial ones. The study demonstrates the positive antioxidant properties of the infusions, which could have health benefits for humans.
A systematic review was conducted to identify potential neuroprotective drugs for the digestive form of Chagas disease, which is currently treated ineffectively. Eight experimental studies on murine models were included, with most showing neuroprotective activity of the tested drugs (acetylsalicylic acid, cyclophosphamide, and Lycopodium clavatum 13c). However, further study on the mechanisms, safety, and immunogenicity of these drugs is needed. This study provides valuable insight for the development of improved treatments for Chagas disease.
Opium dependence is a serious problem in low and middle-income countries, causing considerable deaths each year. Its impact on stroke is unclear. Researchers conducted a study to evaluate the association between opium dependence and stroke. Results showed a significant association between the two, highlighting the harmful effects of opium use on stroke risk. This study sheds light on the need for public health interventions to address opium addiction to prevent stroke and save lives.
The study investigated the protective effects of barberry root extract and berberine against neuronal damage caused by oxidative stress. They tested this using a human cell line and found that both substances were able to protect against damage induced by hydrogen peroxide. These findings suggest that barberry root extract and berberine could potentially be used to treat neurodegenerative disorders like Alzheimer's disease.
Brucine, a component of Strychnos nux-vomica with potential anti-tumor and anti-inflammatory effects, is limited by its toxicity, especially in the central nervous system. This study found that brucine induces death in nerve cells and astrocytes, and triggers a pathway involving PPARγ/NF-κB/caspase 3-dependent apoptosis. Brucine directly bound to caspase 3, and a caspase 3 inhibitor abolished the neurotoxicity. These findings provide insight into the toxicity mechanism of brucine and suggest a potential strategy for addressing it.