Neuroscience Studies

Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model.

Jatamansinol, a compound extracted from Nardostachys jatamansi used in traditional medicine, has been found to protect against Tau-induced neurotoxicity in a Drosophila model of Alzheimer's Disease (AD). The study investigated the effects of jatamansinol on lifespan, learning and memory, oxidative stress, and cholinesterase activities in tauopathy flies. Results showed that jatamansinol treatment extended lifespan, improved locomotor activity, enhanced learning and memory, and reduced Tau protein levels while boosting antioxidant enzyme activities and inhibiting cholinesterase activities in Tau-induced AD models. These findings suggest jatamansinol could be a potential therapeutic drug candidate for AD.

Neuroscience Nardostachys jatamansi
Anupama KP et al (2022).
Mol Neurobiol.
DOI:
10.1007/s12035-022-02964-7
PubMed:
35864434

Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis.

Researchers investigated the potential of traditional Chinese medicines Schisandra chinensis and Acorus tatarinowii Schott in Alzheimer's disease treatment and found them to have neuroprotective effects. Although the main anti-Alzheimer's compounds and functional mechanisms are unknown, clinical studies have proven their effectiveness. Further research could lead to a better understanding of these traditional medicines and their potential use in treating Alzheimer's disease.

Neuroscience Acorus tatarinowii
Chen J et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/6362617
PubMed:
35860432

[Exploration on mechanism of Polygalae Radix and Acori Tatarinowii Rhizoma in treating Alzheimer's disease based on network pharmacology and experimental verification].

Scientists used network pharmacology, molecular docking, and animal tests to investigate the effects of Polygala tenuifolia and Acorus tatarinowii in treating Alzheimer's disease (AD). By analyzing active ingredients and targets of the traditional Chinese medicines, they identified core targets and pathways involved in AD. Mice with cognitive impairment were given the treatments, which improved learning and memory abilities and reduced neuron damage. The results suggest that P. tenuifolia and A. tatarinowii have potential for treating AD through multiple components, targets, and pathways.

Neuroscience Acorus tatarinowii
Su SJ et al (2022).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20211216.707
PubMed:
35851129

Central nervous system depressant activity of Jatamansi (Nardostachys jatamansi DC.) rhizome.

Sleep disorders are prevalent and pharmacological treatments often have side effects. Researchers suggest exploring natural plant-based sources as a safe and effective alternative. A rhizome commonly used for insomnia and mental conditions in Indian medicine is a promising candidate.

Neuroscience Nardostachys jatamansi
Panara K, Nariya M and Karra N (2020).
Ayu.
DOI:
10.4103/ayu.AYU_251_20
PubMed:
35813358

DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson's disease.

DL-3-n-butylphthalide (NBP), derived from Apium graveolens seeds, has potential therapeutic effects for Parkinson's disease. Researchers established a rat model of the disease and found that NBP alleviated motor disturbance, prevented loss of dopaminergic neurons, reduced iron deposition in the substantia nigra and serum, and inhibited oxidative stress. The expression of iron metabolism-related proteins was altered by NBP treatment. These findings suggest that NBP mitigates Parkinson's disease by inhibiting iron deposition, oxidative stress, and ferroptosis in the substantia nigra.

Neuroscience Apium graveolens
Hu CB et al (2023).
Neural Regen Res.
DOI:
10.4103/1673-5374.343892
PubMed:
35799542

Elucidating the Neuroprotective Effect of Tecoma stans Leaf Extract in STZ-Induced Diabetic Neuropathy.

Researchers are seeking alternative therapies to treat diabetes and limit diabetic complications like diabetic neuropathy. Current therapies only provide temporary relief. Diabetes is on the rise, and scientists are looking towards new methods that can curb its progression.

DiabetesNeuroscience Tecoma stans
Gupta A et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/3833392
PubMed:
35795278

Blood-Brain Barrier Permeability Study of Potential Neuroprotective Compounds Recovered From Plants and Agri-Food by-Products.

Researchers used various extraction techniques to recover bioactive compounds from several plants and woods. These extracts were then tested for their neuroprotective properties and submitted to phytochemical profiling. The most promising extract was from acacia, which showed strong neuroprotective capacity and high perfusion capacity. Tamarillo and rosemary extracts were non-toxic, while acacia and lenga extracts were mild-cytotoxic, and kalanchoe was highly toxic. These extracts could potentially be used to create valuable food additives, supplements, or nutraceuticals with neuroprotective properties.

Neuroscience Cyphomandra betacea
Sánchez-Martínez JD et al (2022).
Front Nutr.
DOI:
10.3389/fnut.2022.924596
PubMed:
35782945

Insecticidal activity of the essential oil of Schinus areira against Rhipibruchus picturatus (F.) (Coleoptera: Bruchinae), and its inhibitory effects on acetylcholinesterase.

During storage of Prosopis alba pods, the seed beetle Rhipibruchus picturatus causes significant loss. Essential oils derived from Schinus areira leaves and seeds, as well as Citrus spp., were found to be effective natural insecticides against R. picturatus. The Schinus areira leaf oil was the most effective and inhibits the acetylcholinesterase enzyme, a key target for insect control. These results suggest that essential oils could be useful pest management tools for reducing losses during Prosopis alba pod storage.

NeurosciencePhytochemistry Prosopis alba
Mattar VT et al (2022).
Pestic Biochem Physiol.
DOI:
10.1016/j.pestbp.2022.105134
PubMed:
35772837
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