Neuroscience Studies

Study of nonlinear optical responses of phytochemicals of Clitoria ternatea by quantum mechanical approach and investigation of their anti-Alzheimer activity with in silico approach.

Researchers conducted a computational investigation of the nonlinear optical responses of active phytochemicals in the Clitoria ternatea plant using density functional theory. Their results identified Clitorin as the most active phytochemical inhibitor of Alzheimer's disease. Molecular dynamics simulations showed the stability of the complex, suggesting its potential as a drug-like molecule against AD. Additionally, the phytochemical showed no harmful effects on the heart. These findings indicate the potential of Clitorin as a therapeutic for Alzheimer's disease.

GeneticsNeurosciencePhytochemistry Clitoria ternatea
Lakhera S et al (2023).
Struct Chem.
DOI:
10.1007/s11224-022-01981-5
PubMed:
35729937

Perilla frutescens seed oil combined with Anredera cordifolia leaf powder attenuates age-related cognitive decline by reducing serum triglyceride and glucose levels in healthy elderly Japanese individuals: a possible supplement for brain health.

Perilla seed oil supplementation improves brain function in elderly Japanese individuals, and the combination of perilla seed oil and perilla leaf powder provides the greatest benefits for cognitive health. This suggests that it may be an effective supplement for brain health in aging populations.

Neuroscience Anredera cordifolia
Hashimoto M et al (2022).
Food Funct.
DOI:
10.1039/d2fo00723a
PubMed:
35722977

Stellerasespenes A‒E: Sesquiterpenoids from Stellera chamaejasme and their anti-neuroinflammatory effects.

Researchers have isolated nine sesquiterpenoids from Stellera chamaejasme roots, five of which are previously undescribed. These were tested for their ability to inhibit NO production in BV2 cells induced by LPS. Stellerasespene A was found to have higher inhibitory activity than minocycline, a positive control, indicating its potential use as an anti-inflammatory agent.

Neuroscience Stellera chamaejasme
Cheng ZY et al (2022).
Phytochemistry.
DOI:
10.1016/j.phytochem.2022.113275
PubMed:
35718134

Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis.

Researchers investigated the effect of cyclotide-rich fractions from Viola odorata, a type of plant protein, on an animal model of MS. MS is a chronic inflammation disease that damages the central nervous system. The study aimed to identify whether cyclotides had immunomodulatory properties that could help treat MS.

ImmunologyNeuroscience Viola odorata
Dayani L et al (2022).
Mult Scler Relat Disord.
DOI:
10.1016/j.msard.2022.103958
PubMed:
35716476

Anti-Alzheimer's disease active components screened out and identified from Hedyotis diffusa combining bioaffinity ultrafiltration LC-MS with acetylcholinesterase.

Researchers investigated the effects of different chemical extract fractions of Hedyotis diffusa on amyloid-beta aggregation, a key process in AD development. They found that the fractions significantly inhibited amyloid-beta aggregation and showed potential as promising sources for AD treatment. The study highlights the importance of exploring traditional remedies in finding new treatments for complex diseases like AD.

Neuroscience Hedyotis diffusa
Li J et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115460
PubMed:
35714878

Antiepileptic Therapy of Abrus cantoniensis: Evidence from Network Pharmacology.

Researchers used network pharmacology to explore the mechanism behind Abrus cantoniensis, an herb used for antiepileptic treatment. Through various databases, they found three active components mainly related to -sitosterol and stigmasterol, 92 intersection targets of epilepsy including 9 core targets, and 8 core targets as flavanone constituent proteins. Additionally, they found that Abrus cantoniensis is mainly connected to epilepsy through the neuroactive ligand-receptor interaction signaling pathway, the neurodegeneration pathway, and multiple disease signaling pathway. The study provides a new strategy for antiepileptic treatment using Abrus cantoniensis.

Neuroscience Abrus cantoniensis
Wang Y et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/7748787
PubMed:
35707480

Isoquinoline Alkaloid Contents in Macleaya cordata Extracts and Their Acetylcholinesterase and Butyrylcholinesterase Inhibition.

The study aimed to optimize a method for determining cholinesterase activity using high-performance liquid chromatography and then investigate the potential of isoquinoline alkaloids and plant extracts for inhibiting acetylcholinesterase and butyrylcholinesterase activity. The HPLC method successfully eliminated interference from certain alkaloids and allowed for identification of bioactive compounds in the plant extracts. Results showed high inhibition activity, particularly in sanguinarine and chelerythrine alkaloids and the May aerial plant extract. These extracts may be recommended for further in vivo testing to confirm cholinesterase inhibition activity.

NeurosciencePhytochemistry Macleaya cordata
Tuzimski T et al (2022).
Molecules.
DOI:
10.3390/molecules27113606
PubMed:
35684539

Pharmacological, Neurochemical, and Behavioral Mechanisms Underlying the Anxiolytic- and Antidepressant-like Effects of Flavonoid Chrysin.

Chrysin, a natural molecule found in plants, has various health benefits such as antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Researchers have found that chrysin also exhibits anxiolytic and antidepressant-like effects through its interaction with neurotransmitter systems, particularly the GABAergic and serotonergic, and activation of neurotrophic factors. The antioxidant and anti-inflammatory activities of chrysin may also contribute to its therapeutic use for anxiety and depression disorders. These pre-clinical findings suggest that chrysin could be a promising novel therapy for these disorders.

NeurosciencePhytochemistry Passiflora incarnata
Rodríguez-Landa JF et al (2022).
Molecules.
DOI:
10.3390/molecules27113551
PubMed:
35684488
1 107 116 117 118 127 171