Neuroscience Studies

Network pharmacology analysis reveals neuroprotection of Gynostemma pentaphyllum (Thunb.) Makino in Alzheimer' disease.

Chinese medicinal herb Gynostemma Pentaphyllum (Thunb.) Makino (GpM) has been reported to ameliorate cognitive impairment in Alzheimer's disease (AD), but its neuroprotective mechanism remains unclear. Researchers aimed to investigate the targets and possible signaling pathways of GpM in the treatment of AD. GpM's anti-inflammatory, anti-oxidative stress, and anti-tumor properties make it a promising candidate for AD drug treatment.

Neuroscience Gynostemma pentaphyllum
Wang J et al (2022).
BMC Complement Med Ther.
DOI:
10.1186/s12906-022-03534-z
PubMed:
35255879

Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe(3)O(4) nanoparticles.

This study developed a new screening tool to find drugs to treat Alzheimer's disease by inhibiting acetylcholinesterase (AChE), an enzyme that deactivates the cognitive chemical acetylcholine. The researchers immobilized AChE on magnetic nanoparticles and optimized the process to maximize enzyme immobilization yield. They then used this tool to screen natural products and found four compounds that successfully inhibited AChE - one of which was more potent than the current treatment, tacrine. This approach could be useful for discovering target drugs from complex matrices.

Neuroscience Selaginella doederleinii
Zhang F et al (2022).
Talanta.
DOI:
10.1016/j.talanta.2022.123284
PubMed:
35255433

Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects Aβ(42)-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model.

A study analyzed the effect of jatamansinol, an active compound in an essential Indian Ayurvedic plant, on neuroprotection against Alzheimer's disease (AD) in a Drosophila AD model. Flies supplemented with jatamansinol showed extended lifespan, enhanced learning and memory, improved locomotor abilities, reduced Aβ protein levels, and prevented oxidative stress-induced eye degeneration and cholinesterase activities. Jatamansinol showed neuroprotective effects against Aβ protein-induced neurotoxicity in the AD model, suggesting its therapeutic potential against AD.

Neuroscience Nardostachys jatamansi
Anupama KP et al (2022).
Neurotoxicology.
DOI:
10.1016/j.neuro.2022.02.011
PubMed:
35247505

Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.

Researchers studied whether Tabebuia impetiginosa bark could be used to treat Parkinson's disease. This bark has been used as a tonic and for motor disorders. The study used experimental methods to explore its activity in treating Parkinson's.

Neuroscience Tabebuia impetiginosa
Pal Roy S et al (2022).
Ann Pharm Fr.
DOI:
10.1016/j.pharma.2022.02.007
PubMed:
35240121

Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway.

Geraniin, a polyphenol, was studied for its potential to protect against cerebral ischemia/reperfusion (I/R) injury. The study used both in vivo and in vitro models to evaluate the neuroprotective effect of geraniin. Geraniin showed a significant reduction in infarct volume, decreased neurological deficit scores, and reduced cell apoptosis. It also increased the activity of superoxide dismutase (SOD) and decreased the activity of lactate dehydrogenase (LDH) and malondialdehyde (MDA), suggesting its antioxidant capacity. Additionally, geraniin increased Nrf2/HO-1 protein expression in vivo and in vitro, indicating an association with the protective effect against I/R injury. Geraniin shows promise as a potential treatment for ischemic stroke.

CardiologyImmunologyNeuroscience Phyllanthus amarus
Yang Y et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/2152746
PubMed:
35222793

Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis.

Scientists investigated whether extracts from the Bauhinia championii plant could prevent neuronal injury caused by cerebral ischemia/reperfusion (I/R), which currently lacks effective remedies and can result in lethal injury. BCEs have previously shown anti-oxidative and anti-hypoxia properties. The study's findings suggest that BCE may be a potential treatment for I/R-induced neuronal injury.

CardiologyNeuroscience Bauhinia championii
Huang M et al (2022).
Curr Med Sci.
DOI:
10.1007/s11596-022-2525-4
PubMed:
35220494

Datura stramonium abrogates depression- and anxiety-like disorders in mice: possible involvement of monoaminergic pathways in its antidepressant activity.

Researchers investigated the antidepressant and anxiolytic properties of a certain plant called HLDS, which is traditionally used to manage mental health issues. They studied its effects on mice and tried to understand how it works. The findings suggest that HLDS has therapeutic potential for mental health disorders in humans.

Neuroscience Datura stramonium
Akanji MA et al (2022).
Drug Metab Pers Ther.
DOI:
10.1515/dmpt-2021-0166
PubMed:
35218173

Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.

Kurarinone, a natural compound, can potentially treat Parkinson's disease (PD) by inhibiting the soluble epoxide hydrolase (sEH) enzyme. In a study, kurarinone alleviated MPTP-induced behavioral deficits, dopaminergic neurotoxicity, and neuroinflammation in mice. Kurarinone's inhibition of sEH was supported by evidence of increased sEH substrates and decreased products, along with inhibition kinetics and cocrystallization. The study suggests that sEH is a promising target for PD treatment and that kurarinone could be a natural candidate for it.

Neuroscience Sophora flavescens
Sun CP et al (2022).
Proc Natl Acad Sci U S A.
DOI:
10.1073/pnas.2118818119
PubMed:
35217618
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