Protective effect of Artemisia absinthium on 6-hydroxydopamine-induced toxicity in SH-SY5Y cell line.

This study explored the potential of to protect against the loss of dopaminergic neurons associated with Parkinson's disease. The researchers conducted experiments using SH-SY5Y cells and found that had neuroprotective and antioxidant effects on 6-OHDA-induced toxicity. These findings suggest that may have potential therapeutic benefits for individuals living with Parkinson's disease.

Rashidi R et al (2021).

Avicenna J Phytomed.

PubMed:

34046320

Dihydromyricetin attenuates D-galactose-induced brain aging of mice via inhibiting oxidative stress and neuroinflammation.

Researchers investigated the effects of dihydromyricetin (DMY), a natural product found in Ampelopsis grossedentata, on brain aging in mice. The study found that DMY showed strong neuroprotective effects, improved spatial cognition, alleviated damage of hippocampal neurons, and inhibited senescence of hippocampal neurons. Additionally, DMY modulated oxidative stress and inflammation-related senescence of hippocampal neurons. These findings suggest that DMY may be a potential treatment for brain aging-related diseases.

Qian J et al (2021).

Neurosci Lett.

DOI:

10.1016/j.neulet.2021.135963

PubMed:

34022267

In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease.

Turkish sage, a species traditionally used to improve cognition, has anticholinergic effects and is a potential natural treatment for Alzheimer's disease. This study aimed to understand the mechanism behind its neuroprotective effects and investigate the inhibitory effects of its major compound, rosmarinic acid, on enzymes related to Alzheimer's disease. Results showed that the infusion significantly decreased amyloid beta-induced cytotoxicity and exhibited promising inhibitory activity against key enzymes. The study provides proof of the infusion's potential as a natural treatment for Alzheimer's disease.

Gürbüz P et al (2021).

Saudi Pharm J.

DOI:

10.1016/j.jsps.2021.01.007

PubMed:

33981172

Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model.

Rapaka D et al (2021).

Neuropeptides.

DOI:

10.1016/j.npep.2021.102151

PubMed:

33932860

Neuroprotective and Antioxidant Enhancing Properties of Selective Equisetum Extracts.

This study investigated the chemical composition and biological effects of extracts from the species, commonly used in traditional medicine. Using ultra-high-performance liquid chromatography, chemical characterization was performed, and in vitro antioxidant activity was evaluated. In vivo tests using zebrafish revealed that one extract had significant anxiolytic and antidepressant effects, while another had significant antioxidant activity. These results suggest the potential of these extracts for treating various medical conditions, and provide insight into their active ingredients.

Batir-Marin D et al (2021).

Molecules.

DOI:

10.3390/molecules26092565

PubMed:

33924900

Contribution of Attenuation of TNF-α and NF-κB in the Anti-Epileptic, Anti-Apoptotic and Neuroprotective Potential of Rosa webbiana Fruit and Its Chitosan Encapsulation.

The anti-convulsant effect of -hexane extract of fruit of L. was studied in a PTZ-induced animal model of epilepsy. Rats were treated with the extract or control, scored for convulsive behavior and seizures, and their brains analyzed. The extract significantly reduced seizures and increased survival rates. It also downregulated neuro-inflammation and expression of cytokine TNF-α and transcription factor NF-κB, and had various chemical constituents. The findings suggest potential for L. as an anti-convulsant agent.

Firdous A et al (2021).

Molecules.

DOI:

10.3390/molecules26082347

PubMed:

33920713

Cymbopogon citratus (DC.) Stapf, citral and geraniol exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in zebrafish.

C. citratus has been used as a traditional medicine due to its neurological effects. Researchers are exploring its potential as an alternative treatment for epilepsy, as current drugs have side effects.

Hacke ACM et al (2021).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2021.114142

PubMed:

33910044

Comparative taxonomic variation in fruits and seeds' surface morphology among populations of alpine Rosa sericea complex (Rosaceae).

This study examined the surface features of fruits and seeds of three taxa of the Rosa sericea complex to determine their taxonomic significance and delimitation. The researchers used scanning electron microscopy to observe the surface micro-morphological characters and found 44 different qualities. They also used principal component analysis to analyze the relationship between the studied characters. Density of stomata and trichomes were observed more on the dorsal and ventral parts of the seeds than on the lateral parts. Persistent calyx shape, fruit and seed shape, stomata shape, and trichome size were significant factors in distinguishing between the taxa. This study aims to provide identification keys for the Rosa sericea complex based on fruit and seed morphology.

Ullah F et al (2021).

Microsc Res Tech.

DOI:

10.1002/jemt.23788

PubMed:

33908115