Neuroscience Studies

Modulatory Effects of Cannabis Sativa Co-administration with Tramadol and Codeine on Cognitive Function in Male Rats.

This study examined the effects of combining codeine, tramadol, and Cannabis sativa on the brain function of rats. The results showed that prolonged administration of these substances suppressed cognitive function and enzyme activities, leading to neurotoxicity.

Neuroscience Cannabis sativa
Ademosun AO et al (2023).
Neurotoxicology.
DOI:
10.1016/j.neuro.2023.08.005
PubMed:
37652187

Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats.

High salt intake causes neurological damage in hypertensive rats. Barley extract reduces blood pressure, oxidative stress, inflammation, and restores neurotransmitter balance, suggesting it could be a treatment for high salt-induced hypertension and neurodegenerative diseases.

ImmunologyNeuroscience Hordeum vulgare
Ahmed-Farid OA et al (2023).
Metab Brain Dis.
DOI:
10.1007/s11011-023-01277-5
PubMed:
37646962

Neuroprotective effect of Potentilla reptans L. root in the rat brain global ischemia/reperfusion model.

Potentilla reptans root extract shows potential for protecting the brain and reducing beta-amyloid in a rat model, indicating possible benefits for stroke and neurodegenerative diseases.

CardiologyNeuroscience Potentilla reptans
Noorgaldi S et al (2023).
Arch Pharm (Weinheim).
DOI:
10.1002/ardp.202300363
PubMed:
37642540

Pomegranate (Punica granatum L.) and its phytochemicals as anxiolytic; an underreported effect with therapeutic potential: a systematic review.

A systematic review found that pomegranate and its phytochemicals have an anxiolytic-like effect, potentially providing an alternative treatment for anxiety. Mechanisms of action include GABAergic receptor inhibition and modulation of oxidative stress, cytokines, and gene expression.

Neuroscience Punica granatum
Flores-Bazán T et al (2023).
Brain Res.
DOI:
10.1016/j.brainres.2023.148554
PubMed:
37640097

Exploring the multi-gene regulatory molecular mechanism of Saudi Arabian flora against epilepsy based on data mining, network pharmacology and docking analysis.

Saudi scientists identify potential anti-epileptic compounds from local flora using network pharmacology and bioinformatics, supported by molecular docking experiments. This research informs future development of epilepsy treatments.

GeneticsNeuroscience Abrus precatoriusAzadirachta indicaSolanum incanumWithania somnifera
Falah Alshehri F et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.101732
PubMed:
37638220

Linking traditional medicine to modern phytotherapy: Chemical characterization and assessment of antioxidant and anticholinesterase effects in vitro of a natural Persian remedy for dementia.

An improved formulation from Traditional Persian Medicine (TPM) containing a mixture of plants exhibits antioxidant and anti-cholinesterase properties, potentially making it a useful natural remedy for dementia. Further studies are needed for safety and efficacy.

ImmunologyNeuroscience Cinnamomum cassiaPistacia lentiscusRheum palmatumSyzygium aromaticum
Peron G et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115674
PubMed:
37634357

Dietary Flaxseed and Flaxseed Oil Differentially Modulate Aspects of the Microbiota Gut-Brain Axis Following an Acute Lipopolysaccharide Challenge in Male C57Bl/6 Mice.

Flaxseed can potentially reduce inflammation caused by endotoxins through its effects on the gut microbiota, independent of its content of alpha-linolenic acid. This study suggests flaxseed as a dietary supplement for mental health and neurological disorders.

GastroenterologyNeuroscience Linum usitatissimum
Livingston DBH et al (2023).
Nutrients.
DOI:
10.3390/nu15163542
PubMed:
37630732

From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders.

Plant-derived bioactive compounds, such as vitamin C, polyphenols, curcumin, and resveratrol, have antioxidant and neuroprotective properties, suggesting potential for treating oxidative stress-related diseases like MDD, ASD, ADHD, and neurodegenerative disorders. Additional clinical research is needed to confirm their therapeutic benefits.

Neuroscience Crocus sativusHypericum perforatum
Grosso C, Santos M and Barroso MF (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12081603
PubMed:
37627598
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