Hydroalcoholic extract of Passiflora incarnata improves the autistic-like behavior and neuronal damage in a valproic acid-induced rat model of autism.

Passiflora extract reduces behavioral abnormalities and oxidative stress markers caused by prenatal VPA exposure, offering potential natural treatment for conditions like autism and ADHD.

Amini F et al (2023).

J Tradit Complement Med.

DOI:

10.1016/j.jtcme.2023.02.005

PubMed:

37396155

Deacetyl epoxyazadiradione ameliorates BPA-induced neurotoxicity by mitigating ROS and inflammatory markers in N9 cells and zebrafish larvae.

A study investigates the potential protective effects of a neem-derived compound, DEA, against the harmful effects of BPA exposure. DEA reduced cell damage in N9 cells and improved antioxidant production in zebrafish larvae, suggesting its ability to mitigate oxidative stress and inflammation caused by BPA.

Murugan R et al (2023).

Comp Biochem Physiol C Toxicol Pharmacol.

DOI:

10.1016/j.cbpc.2023.109692

PubMed:

37394128

Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice.

Researchers found that a mutant rice resistant to the striped stem borer (SSB) lacks serotonin, which promotes SSB growth. This suggests that reducing serotonin levels could help breed SSB-resistant rice varieties.

Wang L et al (2023).

J Pineal Res.

DOI:

10.1111/jpi.12895

PubMed:

37392131

Exosome-like nanoparticles derived from Allium tuberosum prevent neuroinflammation in microglia-like cells.

Ishida T et al (2023).

J Pharm Pharmacol.

DOI:

10.1093/jpp/rgad062

PubMed:

37390476

Concept of dementia (Nisy ā n) in Unani system of medicine and scientific validation of an important Unani pharmacopoeial preparation 'Majoon Vaj' for its management: a review.

This review examines the Unani system's understanding of dementia, focusing on phytochemistry, nootropic, and CNS activities. It suggests potential directions for future research and enhances our understanding of dementia.

Aleem M and Khan MI (2023).

J Complement Integr Med.

DOI:

10.1515/jcim-2021-0447

PubMed:

37384842

Exploring the Mechanism of Arctium Lappa L. Leaves in the Treatment of Alzheimer's Disease Based on Chemical Profile, Network Pharmacology and Molecular Docking.

Burdock leaves show potential in treating Alzheimer's Disease (AD) due to their bioactive ingredients. Chemical profiling and network pharmacology found 61 components and 792 targets, with 36 potential targets and four clinically significant targets identified. Therapeutic mechanisms involve the PI3K-Akt and AGE-RAGE signaling pathways.

Mu SC et al (2023).

Adv Biol (Weinh).

DOI:

10.1002/adbi.202300084

PubMed:

37382195

Datura metel stramonium exacerbates behavioral deficits, medial prefrontal cortex, and hippocampal neurotoxicity in mice via redox imbalance.

Study investigates effects of Datura metel extract on the brain; aims to determine if oral exposure increases oxidative stress in mPFC and hippocampus, leading to behavioral deficits in mice.

Igben VO et al (2023).

Lab Anim Res.

DOI:

10.1186/s42826-023-00162-7

PubMed:

37381025

Abelmoschus eculentus Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer's Potential Supported by Metabolomic and Computational Investigation.

Okra fruit extract shows significant anti-Alzheimer's activity in vitro and in vivo, improving symptoms and biomarkers in a rat model. Metabolomic and network pharmacology studies reveal connections between compounds in the extract and genes related to Alzheimer's disease. Promising dietary option for managing the disorder.

Bakhsh HT et al (2023).

Plants (Basel).

DOI:

10.3390/plants12122382

PubMed:

37376007