Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: Mechanisms from the perspective of synaptic injury, oxidative stress, and neuroinflammation.

P. cyrtonema Hua is used in traditional Chinese medicine to treat depression syndrome. The study examines the effects of its active component, PSP, on PTSD and its mechanisms. Results are unknown.

Xie P et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117165

PubMed:

37696440

Omics approaches to investigate the neuroprotective capacity of a Citrus sinensis (sweet orange) extract in a Caenorhabditis elegans Alzheimer's model.

New study finds PLE100, an extract from Citrus sinensis by-products, shows promise as a treatment for Alzheimer's disease due to its neuroprotective properties and positive effects on genes and metabolites involved in stress response and lipid metabolism.

Sánchez-Martínez JD, Cifuentes A and Valdés A (2023).

Food Res Int.

DOI:

10.1016/j.foodres.2023.113128

PubMed:

37689893

Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain.

Laurus nobilis L. (a plant) has been used in Tunisian medicine for treating ailments like rheumatism and neurological disorders. This study explores its potential benefits, which could be useful for your lab's research in finding new treatments.

Smach MA et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117151

PubMed:

37689325

Inhibition of Enzymes Involved in Neurodegenerative Disorders and Aβ(1-40) Aggregation by Citrus limon Peel Polyphenol Extract.

Researchers analyzed polyphenols obtained from agro-food industry waste and found that they inhibit key enzymes and reduce oxidative stress in neurogenerative disorders. This study suggests that these compounds could be used in combination with drugs for the prevention and management of Alzheimer's and Parkinson's diseases.

Arcone R et al (2023).

Molecules.

DOI:

10.3390/molecules28176332

PubMed:

37687161

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases.

A group of compounds called Avenanthramides found in oats have antioxidant, anti-inflammatory, and anti-apoptotic properties. They can potentially modulate the PI3K signaling pathway, which is implicated in neurodegenerative diseases. More research is needed to understand how they work and their potential as a therapeutic strategy.

Wankhede NL et al (2023).

Nutrients.

DOI:

10.3390/nu15173751

PubMed:

37686782

PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer's Disease Defects By Inducing Autophagy in Mice Models.

Krishnamoorthi S et al (2023).

J Neuroimmune Pharmacol.

DOI:

10.1007/s11481-023-10083-w

PubMed:

37682502

A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease.

Scientists found that a compound called 20C derived from Gastrodia elata inhibits the aggregation of α-synuclein, a protein linked to Parkinson's disease. In tests on mice, 20C reduced α-synuclein levels, improved behavior, and protected mitochondrial function. Promising for PD treatment.

Peng Y et al (2023).

Cell Death Dis.

DOI:

10.1038/s41419-023-06116-0

PubMed:

37673867

Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: touch-evoked response and light/dark transition.

Zebrafish study shows two Chinese herbal products had behavioral effects, suggesting combination assays as useful for safety assessment.

Romero NG et al (2023).

Reprod Toxicol.

DOI:

10.1016/j.reprotox.2023.108469

PubMed:

37673194