The effect of calorie-restriction along with thylakoid membranes of spinach on the gut-brain Axis Pathway and oxidative stress biomarkers in obese women with polycystic ovary syndrome: a Randomized, Double-blind, placebo-controlled clinical trial.

In this study, researchers investigated the effects of spinach supplementation and a hypocaloric diet on women with polycystic ovary syndrome (PCOS). They found that this intervention improved gut health, neurotrophic factor levels, and oxidative stress in PCOS patients.

Nikrad N et al (2023).

J Ovarian Res.

DOI:

10.1186/s13048-023-01288-x

PubMed:

37968684

Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.

Ginger powder can potentially alleviate cognitive impairment caused by ethanol abuse by regulating NMDA and GABA-A receptors, reducing oxidative damage, and inhibiting the NF-κB/TNF-α/IL-1β pathway in the rat hippocampus.

Wang J et al (2023).

Metab Brain Dis.

DOI:

10.1007/s11011-023-01301-8

PubMed:

37966694

Gastrodia elata specific miRNA attenuates neuroinflammation via modulating NF-κB signaling pathway.

Gas-miR2-3p, derived from oral administration, reduces inflammatory factors TNF-α, IL-6, and IL-1β in both cells and animals. It also downregulates p-p65 and p-IκBα, alleviating neuroinflammation by modulating the NF-κB signaling pathway. MiRNAs have potential as novel regulators for neuroinflammation.

Fu J et al (2023).

Int J Neurosci.

DOI:

10.1080/00207454.2023.2280835

PubMed:

37965801

Neuroprotective effects of trigonelline in kainic acid-induced epilepsy: Behavioral, biochemical, and functional insights.

Trigonelline, found in fenugreek seeds, shows potential as an anti-epileptic agent by reducing intrasynaptosomal calcium levels, inhibiting oxidative stress, and regulating cytokines in a kainic acid-induced epilepsy model. It improves behavior, provides neuroprotection, and reduces inflammation.

Faizan M et al (2023).

Saudi Pharm J.

DOI:

10.1016/j.jsps.2023.101843

PubMed:

37961069

Flaxseed Oil (Linum usitatissimum) Prevents Cognitive and Motor Damage in Rats with Hyperammonemia.

Flaxseed oil can prevent cognitive and motor impairment in rats with hyperammonemia, offering a potential treatment for hepatic encephalopathy and protecting the brain from damage.

Ocaña-Sánchez MF et al (2023).

Nutrients.

DOI:

10.3390/nu15214550

PubMed:

37960203

Emodin-8-O-Glucoside-Isolation and the Screening of the Anticancer Potential against the Nervous System Tumors.

Emodin-8-glucoside, derived from emodin, shows potential as an antitumor compound in neuroblastoma and glioblastoma cells, inhibiting cell viability and proliferation in a dose-dependent manner. It could be a promising therapy for nervous system tumors.

Okon E et al (2023).

Molecules.

DOI:

10.3390/molecules28217366

PubMed:

37959784

Clavulanic Acid Improves Memory Dysfunction and Anxiety Behaviors through Upregulating Glutamatergic Transporters in the Nucleus Accumbens of Mice Repeatedly Exposed to Khat Extract.

The scientists found that clavulanic acid, a β-lactam-containing compound, can improve memory impairment and anxiety-like behaviors caused by khat exposure in mice. This is achieved by upregulating GLT-1 in the nucleus accumbens. This suggests that β-lactam-containing compounds may be effective in reducing the negative effects of khat use.

Arab AO et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms242115657

PubMed:

37958641

HH-A, a modified honokiol, protects against cerebral ischemia/reperfusion induced brain injury in rodent via Nrf2/HO-1 signaling pathways.

Zhang Y et al (2024).

Naunyn Schmiedebergs Arch Pharmacol.

DOI:

10.1007/s00210-023-02816-8

PubMed:

37955691