Neuroscience Studies

Kaempferol-3-O-sophoroside contributes to modulation of depressive-like behavior in C57BL/6J mice by activating AMPK.

Researchers studied the main component in saffron, PCS-1, and its effect on a potential therapeutic target for depression called AMPK. They found that PCS-1 has antidepressive properties by activating AMPK. This suggests that targeting AMPK could be beneficial for treating depression.

Neuroscience Crocus sativus
Wang R et al (2023).
Br J Pharmacol.
DOI:
10.1111/bph.16283
PubMed:
37949672

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study.

Study found GXDSDP significantly improved anxiety and depression symptoms in CHD patients. Potential alternative treatment option for mental health in cardiovascular disease.

CardiologyNeuroscience Panax notoginseng
Wu SH et al (2024).
Chin J Integr Med.
DOI:
10.1007/s11655-023-3628-x
PubMed:
37947990

Ononin ameliorates depression-like behaviors by regulating BDNF-TrkB-CREB signaling in vitro and in vivo.

Ononin, found in medicinal plants, has anti-inflammatory, antioxidant, and antitumor effects. Flavonoids, like ononin, treat major depression, but the exact mechanisms are unknown.

Neuroscience Ononis spinosaSophora flavescens
Gong G et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117375
PubMed:
37944872

Antioxidant activity of Carica papaya & Persea americana fruits against cadmium induced neurotoxicity, nephrotoxicity, and hepatotoxicity in rats with a computational approach.

Researchers investigated the harmful effects of cadmium on cells, including liver damage, neurotoxicity, and cancer. Current treatments have side effects, so finding safe ways to remove cadmium from the body is crucial.

ImmunologyNeuroscience Carica papayaPersea americana
Anjum S et al (2023).
J Trace Elem Med Biol.
DOI:
10.1016/j.jtemb.2023.127324
PubMed:
37944220

Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.

This study found that crocetin, an active ingredient in saffron, has a rapid antidepressant effect. It reduced depressive-like behaviors, neuroinflammation, and nerve injuries in mice by suppressing inflammatory cytokines and apoptosis through the PI3K/AKT signaling pathways. The effect lasted for at least 2 days after a single treatment.

Neuroscience Crocus sativus
Lin S et al (2023).
Neurochem Res.
DOI:
10.1007/s11064-023-04051-2
PubMed:
37935859

Radioprotective effect of Ginkgolide B on brain: The mediating role of DCC/MST1 signaling.

Ginkgolide B (GB) from ginkgo biloba leaves shows potential protective effects on radiation-induced brain injury (RBI) by regulating the Hippo signaling pathway, suggesting its value for mitigating neurological complications and developing treatments.

Neuroscience Ginkgo biloba
Yang T, Du X and Xu L (2023).
Int J Radiat Biol.
DOI:
10.1080/09553002.2023.2281515
PubMed:
37934907

Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation.

Kaempferol-3-O-glucoside (K-3-G), a flavonoid in Cuscuta Chinensis Lam., improved cognition and reduced inflammation in aging mice. It activated estrogen receptors (ERs) and inhibited microglial inflammation through ERs, suggesting it could be a therapeutic agent for cognitive decline.

EndocrinologyImmunologyNeuroscience Cuscuta chinensis
Liu H et al (2023).
Exp Cell Res.
DOI:
10.1016/j.yexcr.2023.113849
PubMed:
37926343

Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.

This study investigates the role of gut microbiota in the anticonvulsant effect of basil oil. Understanding this relationship could lead to improved treatment options for epilepsy patients who do not respond to current medications. Basil oil has shown promising results in blocking seizures in previous studies.

GastroenterologyNeuroscience Ocimum basilicum
Amidu SB et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04211-5
PubMed:
37924049
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