Depression may be linked with inflammatory bowel disease (IBD). Researchers have found that intestinal inflammation might be a contributing factor to depression, but the exact cause is unknown. This suggests that new treatments for depression targeting the gut may be necessary.
A study found that GBDPs derived from GBE can improve angina frequency and quality of life in patients with stable angina pectoris and depression symptoms, suggesting potential usefulness as treatment.
Cynanchum paniculatum has been traditionally utilized in East Asia as an analgesic or antiviral. Some traditional medicinal books also mention its use in treating psychotic symptoms. The study explores its potential benefits for treating schizophrenia-like symptoms in rats. The extracts showed a promising reduction in behavioral abnormalities, leading to the possibility of this plant being a useful resource in the development of antipsychotic medicines.
The study investigated the effects of a plant extract (OB) on learning and memory in aged rats. Aging decreased cognitive function and increased inflammation and oxidative damage in the brain. However, OB administration for 8 weeks improved learning and memory and reduced inflammation and oxidative damage in the brain. This suggests that OB has neuroprotective effects and may be useful in treating age-related cognitive decline.
A natural antioxidant formula (NAF) composed of several beneficial compounds was given to rats in this study, who were also induced with lipopolysaccharide (LPS)-induced cognitive dysfunction. The NAF decreased inflammation in the brain and increased the number of neural progenitor cells, ultimately ameliorating the detrimental effects on neurogenesis and fear memory caused by LPS-induced inflammation. These findings suggest that NAF could be utilized to prevent neuroinflammation, which is thought to contribute to cognitive dysfunction.
Studies have identified lettuce's sleep-promoting effects and related mechanisms. While it is traditionally known to have hypnotic and sedative effects, few studies have explored this.
Vitis vinifera contains dietary stilbenoids that benefit neuronal disorders related to cognitive impairment. This study investigated the effects of vitisin A, a resveratrol tetramer derived from V. vinifera stembark, on cognitive functions. In in vitro and ex vivo experiments, vitisin A increased cell survival and restored synaptic mechanisms of learning and memory. In vivo experiments showed that vitisin A ameliorated memory function disruptions in mice and upregulated BDNF-CREB signaling in the hippocampus. Overall, vitisin A exhibits neuroprotective effects by upregulating BDNF-CREB signaling and LTP, making it a potential therapeutic agent for neurodegenerative disorders.