Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen-isoflavones in neurodegenerative disorders.

The review article discusses the potential neuroprotective properties of phytoestrogen-isoflavones present in Trifolium pratense (Red clover) for the treatment of neurodegenerative disorders. Studies have shown that Trifolium pratense contains more than 30 isoflavone compounds, including biochanin A, daidzein, formononetin, and genistein. These compounds have been found to exhibit therapeutic efficacy against different neurodegenerative disorders through molecular interactions with estrogenic receptors, anti-inflammatory, anti-oxidative, antiapoptotic, and autophagic inducing mechanisms. The review provides detailed molecular mechanisms and experimental key findings for the clinical use of Trifolium pratense-derived isoflavones for the treatment of neurodegenerative disorders.

Al-Shami AS, Essawy AE and Elkader HAEA (2023).

Phytother Res.

DOI:

10.1002/ptr.7870

PubMed:

37195042

Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders.

Age-related neurological disorders (ANDs) are multifactorial diseases whose risk increases with age, characterized by oxidative stress, impaired mitochondrial function, and neuronal cell death. Black pepper has many health benefits, including neuroprotective properties, due to its active compound piperine. Recent studies have shown that piperine effectively prevents AND symptoms by modulating cell survival signaling and death. Novel nanodelivery systems are being developed to improve the efficacy and bioavailability of black pepper in experimental models, including clinical trials. Black pepper and its active ingredients have therapeutic potential for ANDs.

Balakrishnan R et al (2023).

Aging Dis.

DOI:

10.14336/AD.2022.1022

PubMed:

37191428

Promising effect of Geranium robertianum L. leaves and Aloe vera gel powder on Aspirin(®)-induced gastric ulcers in Wistar rats: anxiolytic behavioural effect, antioxidant activity, and protective pathways.

The effectiveness of traditional drugs for gastric ulcers (GU) is limited, so researchers looked at natural remedies such as Aloe vera and Geranium robertianum. They assessed their ability to protect against Aspirin®-induced GU in rats. The results suggest that these herbal extracts may be promising alternatives for the treatment of GU.

Bawish BM et al (2023).

Inflammopharmacology.

DOI:

10.1007/s10787-023-01205-0

PubMed:

37184667

Phytoecdysteroids from Dianthus superbus L.: Structures and anti-neuroinflammatory evaluation.

Hou XL et al (2023).

Phytochemistry.

DOI:

10.1016/j.phytochem.2023.113710

PubMed:

37178942

Multi-Targeting Neuroprotective Effects of Syzygium aromaticum Bud Extracts and Their Key Phytocompounds against Neurodegenerative Diseases.

The study investigated the neuroprotective properties of clove extract and its bioactive compounds on oxidative stress in human neuroblastoma cells. The extracts reduced reactive oxygen species, restored mitochondrial function, lowered lipid peroxidation, and displayed anti-acetylcholinesterase activity. Clove's multitarget approach may make it a potential candidate for developing Alzheimer's disease drugs as it could be a safer therapy capable of aiding multiple aspects of the disease, an area where current drugs struggle.

Sharma H et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms24098148

PubMed:

37175851

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.

This study explores the harmful effects of opioids, their impact on addiction and overdose, and the involvement of the mesocorticolimbic dopaminergic circuitry. It also addresses the use of synthetic opioids in athletes and the potential for doping.

Mazzeo F, Meccariello R and Guatteo E (2023).

Int J Mol Sci.

DOI:

10.3390/ijms24097831

PubMed:

37175536

Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.

Researchers have found that quercetagitrin, a natural compound from African marigold, can inhibit tau aggregation and reduce tau phosphorylation in vitro. In vivo studies showed that oral administration of the compound restored cognitive deficits and neuron loss and prevented the formation of NFTs and tau phosphorylations in P301S-tau transgenic mice. Quercetagitrin also inhibited neuroinflammation through the inhibition of NF-κB activation. These findings suggest that quercetagitrin has potential as a therapeutic medicine for Alzheimer's disease and other tauopathies.

Zhong S et al (2023).

Molecules.

DOI:

10.3390/molecules28093964

PubMed:

37175376

The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity.

Stinging nettle, a commonly found plant, has been used for various purposes including nutrition, cosmetics, and pharmacology. Its bioactive chemical constituents have been studied for their therapeutic applications. Research shows that compounds found in stinging nettle can provide neuroprotective effects, which could be used to develop tools against neurodegenerative diseases. This review highlights the computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of stinging nettle and its potential implications for neurodegenerative diseases.

Semwal P et al (2023).

Nat Prod Bioprospect.

DOI:

10.1007/s13659-023-00380-5

PubMed:

37171512