Neuroscience Studies

Efficacy of a mixture of Ginkgo biloba, sesame, and turmeric on cognitive function in healthy adults: Study protocol for a randomized, double-blind, placebo-controlled trial.

Researchers investigated the cognitive benefits of Ginkgo biloba extract (GBE) supplemented with sesame seed and turmeric (GBE/MST) in healthy adults. Results showed that GBE/MST improved cognitive function more significantly than GBE alone, possibly due to increased terpene lactone concentrations in the brain. These findings suggest that GBE/MST could be a promising natural intervention for cognitive enhancement in healthy adults.

Neuroscience Ginkgo biloba
Nakase T et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0280549
PubMed:
36921003

Study protocol for a phase III randomised controlled trial of Sailuotong (SLT) for vascular dementia and Alzheimer's disease with cerebrovascular disease.

A new herbal formulation called Sailuotong (SLT) consisting of extracts from Panax ginseng, Ginkgo biloba, and Crocus sativus was developed and found to enhance cognition in patients with vascular dementia (VaD) in early clinical trials. A phase III clinical trial has been developed to confirm the efficacy and safety of SLT in 238 patients with mild to moderate VaD or VaD mixed with Alzheimer’s disease. Participants will be randomly allocated to receive SLT or placebo capsules for 52 weeks, and primary outcome measures include cognitive and functional assessments. The study aims to provide important data on this novel treatment approach to VaD.

Neuroscience Crocus sativusGinkgo biloba
Karamacoska D et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0265285
PubMed:
36920949

Rhynchophylline alleviates neuroinflammation and regulates metabolic disorders in a mouse model of Parkinson's disease.

Researchers studied the effects of Rhynchophylline (RIN), a compound with anti-inflammatory and neuroprotective properties, on a mouse model of Parkinson's disease (PD). They used a combination of tests and assays to determine that RIN improved behavior, reduced neuron loss, and regulated metabolic disorders in the mice. The study showed that RIN has potential as a therapeutic agent for PD by reducing inflammation, maintaining metabolic balance, and suppressing certain proteins in the brain.

ImmunologyNeuroscience Uncaria rhynchophylla
Zhang C et al (2023).
Food Funct.
DOI:
10.1039/d2fo02939a
PubMed:
36919954

Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.

This study investigated the effects of Withania somnifera (WS) in preventing the neurotoxicity and memory impairments caused by MDMA. Mice were pretreated with vehicle or WSE before being randomly assigned into four groups: saline, WSE, MDMA alone, or WSE plus MDMA. Mice that were treated with only MDMA showed a decrease in dopamine levels and an increase in gliosis and hyperthermia, leading to memory impairments, while mice treated with both WSE and MDMA showed protection against the noxious effects of MDMA. This study suggests that WSE may be beneficial in counteracting the harmful effects of MDMA on the brain.

ImmunologyNeuroscience Withania somnifera
Costa G et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114475
PubMed:
36905810

The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation.

Researchers isolated (-)-Tetrahydroalstonine (THA) and studied its effect on protecting neurons from oxygen-glucose deprivation/re-oxygenation (OGD/R)-induced damage. They pre-treated primary cortical neurons with THA and found it increased cell viability. THA also ameliorated autophagic activity and lysosomal dysfunction, which were present at the early stage of OGD/R. Additionally, THA activated the Akt/mTOR pathway, which was suppressed after OGD/R induction. This study suggests that THA exhibits promising neuroprotective effects against OGD/R-induced neuronal injury through autophagy regulation via the Akt/mTOR pathway.

Neuroscience Alstonia scholaris
Liao Y et al (2023).
Molecules.
DOI:
10.3390/molecules28052370
PubMed:
36903613

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain.

This study investigated the antioxidant and anti-amnesic activities of L. plant. Aqueous extract of dried seeds was fractionated and the active fraction (P.aAF) was analyzed. Behavioral and biochemical studies on mice showed significant results, including an increase in inflexion ratio and reduction in MDA and AChE levels, as well as promotion of CAT, SOD, and GSH levels in the brain. The LD for P.aAF was calculated as 95 mg/Kg/p.o. The findings suggest that the plant's oxadiazole compounds contribute to its beneficial effects.

Neuroscience Pimpinella anisum
Mushtaq A et al (2023).
Molecules.
DOI:
10.3390/molecules28052217
PubMed:
36903462
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